Nagasawa K, Ogamo A, Shinozuka T
J Chromatogr. 1975 Aug 20;111(1):51-6. doi: 10.1016/s0021-9673(01)80145-x.
It was found that triethylammonium cyclamate is converted into N-hepta-fluorobutyrylcyclohexylamine in a high and constant yield by reaction with hepta-fluorobutyric anhydride at 90 degrees for 1 h, and gas chromatography of the product gives a sharp peak that is highly sensitive to an electron capture detector. A useful method for the micro-determination of cyclamates was established by combining this reaction with gas chromatography.
结果发现，氨基磺酸三乙铵在90℃下与七氟丁酸酐反应1小时，能以高且恒定的产率转化为N - 七氟丁酰环己胺，产物的气相色谱分析给出一个对电子捕获检测器高度灵敏的尖锐峰。通过将该反应与气相色谱相结合，建立了一种测定氨基磺酸盐的有用的微量测定方法。
