Dhingra R C, Amat-Y-Leon F, Wyndham C, Wu D, Denes P, Rosen K M
J Clin Invest. 1975 Sep;56(3):555-62. doi: 10.1172/JCI108124.
Electrophysiological studies were performed in 16 patients before and 30 min after intravenous administration of ouabain (0.1 mg/kg). P-A interval (mean+/-SEM) was 40+/-2.1 ms before and 44+/- 1.5 ms after ouabain (P less than 0.001). Atrial effective and functional refractory periods (ERP and FRP) were measured in all patients during sinus rhythm and during driving at equivalent paced rates in 12 patients. The mean atrial ERP and FRP during sinus rhythm were, respectively, 244+/-10.5 and 307+/-11.0 ms before and 253+/-9.7 and 318+/-11.4 ms after infusion of ouabain (NS). Mean atrial ERP and FRP during driving were, respectively, 231+/-15.3 and 264+/-14.9 ms before and 266+/-18.6 and 296+/-19.7 ms after ouabain (P less than 0.01 and P less than 0.01). Mean sinus cycle length and sinus recovery times were, respectively, 887+/-31.2 and 1,113+/-38.7 ms before and 905+/-38.2 and 1,008+/-30.7 ms after infusion of ouabain (NS and P less than 0.005). Calculated sinoatrial conduction times before and after ouabain were 90+/-6.8 and 110+/-8.5 ms, respectively (P less than 0.005). In summary, ouabain produced depression of intraatrial conduction as manifested by increase in P-A interval and atrial effective and functional refractory periods. Ouabain significantly increased calculated sinoatrial conduction time without significant effect on spontaneous sinus cycle length.
对16例患者在静脉注射哇巴因（0.1mg/kg）前及注射后30分钟进行了电生理研究。注射哇巴因前P-A间期（均值±标准误）为40±2.1毫秒，注射后为44±1.5毫秒（P<0.001）。在窦性心律期间对所有患者测量了心房有效不应期和功能不应期（ERP和FRP），并在12例患者中以等效的起搏频率驱动时进行了测量。在窦性心律期间，注射哇巴因前心房ERP和FRP的均值分别为244±10.5和307±11.0毫秒，注射后分别为253±9.7和318±11.4毫秒（无显著性差异）。在驱动期间，注射哇巴因前心房ERP和FRP的均值分别为231±15.3和264±14.9毫秒，注射后分别为266±18.6和296±19.7毫秒（P<0.01和P<0.01）。窦性周期长度均值和窦房结恢复时间在注射哇巴因前分别为887±31.2和1113±38.7毫秒，注射后分别为905±38.2和1008±30.7毫秒（无显著性差异和P<0.005）。注射哇巴因前后计算出的窦房传导时间分别为90±6.8和110±8.5毫秒（P<0.005）。总之，哇巴因导致心房内传导抑制，表现为P-A间期、心房有效不应期和功能不应期增加。哇巴因显著增加了计算出的窦房传导时间，而对自发窦性周期长度无显著影响。
