Ng C K, Husslein P, Constantini R, Dienstl F, Simma H, Gmeiner R
Z Kardiol. 1977 May;66(5):223-30.
The effect of 0.5 mg Ouabain (O) i.v. on sinus node function and on intracardiac conduction was studied by His bundle electrography and atrial stimulation. 7 patients with normal sinus node function and av conduction (group I), 5 patients with sick sinus syndrome (group II), and 5 patients with av block of changing degree (group III) were examined. 2 additional patients had simultaneous sinus node dysfunction and av block (group II/III). The sinus node recovery time was prolonged in 6 patients, the av block was located proximal to the His bundle in 4 patients and distal to the His bundle in 3 patients. The spontaneous sinus rate decreased in group I and remained unchanged in group II and III after O. The PA interval increased slightly after O in groups II and III, the AH interval during sinus rhythm was prolonged after O in groups II and III and in the whole group together. During atrial pacing, the stimulus-His-time was increased in each group when compared at identical stimulation rates. In 4 of 7 patients av block type Wenckebach appeared at a lower stilmulation rate after O. The HV interval remained unaltered after O, the sinus node recovery time varied after O. Phenytoin had no positive effect on the changes observed after O. Unwanted actions of O such as increased bradycardia or increased av conduction disturbances were not observed. O appears to be reasonably safe in most patients with sick-sinus syndrome and changing av block.
通过希氏束电图和心房刺激研究了静脉注射0.5毫克哇巴因（O）对窦房结功能和心内传导的影响。检查了7例窦房结功能和房室传导正常的患者（I组）、5例病态窦房结综合征患者（II组）和5例不同程度房室传导阻滞患者（III组）。另外2例患者同时存在窦房结功能障碍和房室传导阻滞（II/III组）。6例患者的窦房结恢复时间延长，4例患者的房室传导阻滞位于希氏束近端，3例患者的房室传导阻滞位于希氏束远端。注射O后，I组的自发窦性心率下降，II组和III组保持不变。II组和III组注射O后PA间期略有增加，II组、III组及整个组在窦性心律时AH间期在注射O后延长。在心房起搏时，以相同刺激频率比较，每组的刺激-希氏束时间均增加。7例患者中有4例在注射O后以较低刺激频率出现文氏型房室传导阻滞。注射O后HV间期保持不变，窦房结恢复时间在注射O后有所变化。苯妥英对注射O后观察到的变化无积极作用。未观察到O的不良反应，如心动过缓加重或房室传导障碍加重。在大多数病态窦房结综合征和不同程度房室传导阻滞患者中，O似乎相当安全。
