Stip E, Dufresne J, Boulerice B, Elie R
Centre de Recherche Fernand-Seguin de l'Hôpital Louis-H. Lafontaine, Université de Montréal, Montreal, Que.
J Psychiatry Neurosci. 2001 Sep;26(4):330-5.
To assess if the lithium dosage prescribed according to the Pepin method leads to therapeutic serum concentrations of lithium.
For 13 healthy volunteers, the initial daily doses of lithium were calculated according to the Pepin formula with a view to obtaining a serum lithium level of 0.8 mmol/L. Lithium was administered twice daily for 21 days, and blood samples were drawn daily, 12 hours after the last dose was taken. Dosage was adjusted if serum concentrations were below 0.6 mmol/L or above 1.0 mmol/L or if major side effects were reported.
Daily lithium doses ranged from 1050 mg to 1950 mg (mean 1569 mg, standard deviation [SD] 291 mg), The mean serum lithium concentrations for weeks 1, 2 and 3 were 0.74 mmol/L (SD 0.19 mmol/L), 0.67 mmol/L (SD 0.22 mmol/L) and 0.69 mmol/L (SD 0.13 mmol/L), respectively. Within-subject variance was negligible. Sixty-eight percent of the serum lithium concentration measurements fell between 0.57 mmol/L and 0.83 mmol/L, and 84% fell within the recommended therapeutic range of 0.60 mmol/L and 1.20 mmol/L.
The Pepin method is a safe but conservative method for predicting the appropriate daily dose of lithium.
评估根据佩平方法开出的锂盐剂量是否能使血清锂达到治疗浓度。
对13名健康志愿者，根据佩平公式计算锂盐初始日剂量，以期使血清锂水平达到0.8 mmol/L。锂盐每日给药两次，共21天，每天在末次给药12小时后采集血样。若血清浓度低于0.6 mmol/L或高于1.0 mmol/L，或出现严重副作用，则调整剂量。
锂盐日剂量范围为1050 mg至1950 mg（平均1569 mg，标准差[SD] 291 mg）。第1、2和3周的平均血清锂浓度分别为0.74 mmol/L（SD 0.19 mmol/L）、0.67 mmol/L（SD 0.22 mmol/L）和0.69 mmol/L（SD 0.13 mmol/L）。受试者内方差可忽略不计。68%的血清锂浓度测量值在0.57 mmol/L至0.83 mmol/L之间，84%在推荐治疗范围0.60 mmol/L至1.20 mmol/L内。
佩平方法是预测锂盐合适日剂量的一种安全但保守的方法。
