Stapleton D, Kerr D, Gurrin L, Sherriff J, Sly P
School of Public Health, Curtin University of Technology, Perth, Australia.
J Pediatr Gastroenterol Nutr. 2001 Sep;33(3):319-25. doi: 10.1097/00005176-200109000-00017.
Many children with cystic fibrosis grow poorly and are malnourished. This study was undertaken to determine whether extensive anthropometry could detect early signs of malnutrition in prepubertal children with cystic fibrosis to prevent deficits in height and weight.
Height, weight, six skin folds (triceps, subscapular, supraspinale, abdominal, front thigh, and medial calf) and five girths (arm relaxed, forearm, chest, thigh, and calf) were measured in a cross-sectional study of children aged 6 to 11 years with cystic fibrosis.
The children with cystic fibrosis were shorter and lighter for their age and gender than those in the reference groups. The mean weight and height z scores for the girls with cystic fibrosis were lower than those for the boys, significantly so for z weight ( P < 0.05). Although, the mean percent ideal body weight value of 98.6% suggested that the children with cystic fibrosis were adequately nourished, most of the measures of muscularity and adiposity of the children with cystic fibrosis were significantly lower than those of the reference group ( P < 0.05). The z scores of the anthropometric measures revealed that the deficit in muscularity of the children with cystic fibrosis was relatively much greater than the deficit in adiposity.
The percent ideal body weight index does not seem to be an adequate measure of nutritional status in children with cystic fibrosis. Anthropometric assessments should include skin-fold and circumference measurements of numerous sites on the upper and lower body, the trunk, and the limbs to detect deterioration in nutritional status early. Early detection of deficits in nutritional status may result in the adverse effects of malnutrition on height and weight, and possibly clinical status, being prevented.
许多囊性纤维化患儿生长发育不良且营养不良。本研究旨在确定广泛的人体测量能否检测出青春期前囊性纤维化患儿营养不良的早期迹象，以预防身高和体重不足。
在一项对6至11岁囊性纤维化患儿的横断面研究中，测量了身高、体重、六个皮褶厚度（肱三头肌、肩胛下、脊柱上、腹部、大腿前侧和小腿内侧）以及五个围度（手臂放松时、前臂、胸部、大腿和小腿）。
囊性纤维化患儿在年龄和性别匹配的情况下，身高和体重低于参照组。囊性纤维化女童的平均体重和身高z评分低于男童，体重z评分差异有统计学意义（P<0.05）。尽管囊性纤维化患儿的平均理想体重百分比值为98.6%，表明其营养充足，但囊性纤维化患儿的大多数肌肉量和脂肪量测量值均显著低于参照组（P<0.05）。人体测量指标的z评分显示，囊性纤维化患儿的肌肉量 deficit相对比脂肪量 deficit大得多。
理想体重百分比指数似乎并非评估囊性纤维化患儿营养状况的充分指标。人体测量评估应包括对上下身、躯干和四肢多个部位的皮褶厚度和周长测量，以便早期发现营养状况恶化。早期发现营养状况 deficit可能预防营养不良对身高和体重以及可能的临床状况产生的不利影响。
