Scheuller M, Weider D
Department of Otolaryngology, University of California San Francisco, 400 Parnassus Ave., San Francisco, CA 04122-2721, USA.
Otolaryngol Head Neck Surg. 2001 Oct;125(4):299-302. doi: 10.1067/mhn.2001.119139.
To evaluate the long-term outcomes of bariatric surgery with respect to respiratory disturbance index (RDI) in sleep apnea syndrome (SAS).
Case series with long-term follow-up (1 to 12 years).
Private clinic in an academic tertiary referral center.
Fifteen morbidly obese patients (10 men, 5 women) who were referred for the treatment of severe SAS.
For all 15 patients who presented with severe SAS, nasal positive airway pressure breathing was either not available or was not tolerated by the patient; therefore, bariatric surgery was performed as a means of treatment for SAS.
RDIs and minimum oxygen saturation were measured both preoperatively and postoperatively (1 to 12 years after surgery).
Weight loss ranged from 60 to 220 pounds (27 to 100 kg). RDI decreased by at least 55% in each patient, and all patients with tracheostomies (8 of 15) had their tracheostomy tubes removed. Average RDI preoperatively was 96.9 and average RDI postoperatively was 11.3. Results were similar for all 15 patients in that minimum oxygen saturation increased during sleep from an average preoperative minimum oxygen saturation of 58.7% to an average postoperative minimum oxygen saturation of 85.2%.
Bariatric surgery as a means of treating SAS in the morbidly obese provides effective long-term reduction in RDI. Bariatric surgery also significantly improves minimum oxygen saturation in morbidly obese patients with SAS. Biliopancreatic bypass is more effective in reducing RDI to normal values than vertical banded gastroplasty.
评估减肥手术治疗睡眠呼吸暂停综合征(SAS)患者呼吸紊乱指数(RDI)的长期疗效。
长期随访(1至12年)的病例系列研究。
一所学术性三级转诊中心的私人诊所。
15例病态肥胖患者(10例男性,5例女性),因重度SAS前来就诊。
所有15例重度SAS患者均无法获得或无法耐受经鼻持续气道正压通气;因此,实施减肥手术作为SAS的一种治疗手段。
术前及术后(术后1至12年)测量RDI和最低血氧饱和度。
体重减轻范围为60至220磅(27至100千克)。每位患者的RDI至少降低了55%,所有行气管造口术的患者(15例中的8例)均拔除了气管造口管。术前平均RDI为96.9,术后平均RDI为11.3。15例患者的结果相似,即睡眠期间最低血氧饱和度从术前平均最低血氧饱和度58.7%升至术后平均最低血氧饱和度85.2%。
减肥手术作为治疗病态肥胖患者SAS的一种手段,可有效长期降低RDI。减肥手术还能显著提高病态肥胖SAS患者的最低血氧饱和度。胆胰转流术在将RDI降至正常水平方面比垂直束带胃成形术更有效。