Arunkumar M J, Srinivasa Babu K, Chandy M J
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore-632 004, India.
Neurol India. 2001 Sep;49(3):219-24.
Motor and somatosensory evoked potentials (MEP and SSEP) were compared after experimental spinal cord injury in Bonnet monkeys (macaca radiata). The MEP and SSEP changes following graded injuries were related to clinical outcome. Eight healthy mature monkeys with a mean weight of 4.2 + 0.9 Kg were chosen for the study. Graded spinal cord injury was caused using 50, 100, 200, 300 gm-cm force by modified Allens' weight drop device. MEP and SSEP recordings were done before injury and at 0, 2, 4 and 6 hours after injury and on the 7th postoperative day. Neurological assessment was done at 24 hours and on the 7th day following injury. 50, 100, 200 gm-cm force caused partial injuries and 300 gm-cm force caused severe spinal cord injury. The predictive value of MEP and SSEP following partial injuries was 80% and 66.67% respectively. Both MEP and SSEP were 100% predictive in severe injury. MEP and SSEP monitoring can therefore be complementary to each other in predicting the neurological outcome in partial injuries to the spinal cord.
在帽猴（恒河猴）实验性脊髓损伤后，对运动诱发电位（MEP）和体感诱发电位（SSEP）进行了比较。分级损伤后的MEP和SSEP变化与临床结果相关。选择8只平均体重为4.2±0.9千克的健康成年猴子进行研究。使用改良的艾伦氏重物下落装置，以50、100、200、300克 - 厘米的力造成分级脊髓损伤。在损伤前、损伤后0、2、4和6小时以及术后第7天进行MEP和SSEP记录。在损伤后24小时和第7天进行神经学评估。50、100、200克 - 厘米的力造成部分损伤，300克 - 厘米的力造成严重脊髓损伤。部分损伤后MEP和SSEP的预测价值分别为80%和66.67%。在严重损伤中，MEP和SSEP的预测率均为100%。因此，在预测脊髓部分损伤的神经学结果时，MEP和SSEP监测可以相互补充。
