Seo N, Kawashima Y, Irita K, Kobayashi T, Goto Y, Morita K, Iwao Y, Tsuzaki K, Dohi S
Department of Anesthesiology, Jichi Medical School, Tochigi 329-0498.
Masui. 2001 Sep;50(9):1028-37.
The Committee on Operating Room Safety of Japanese Society of Anesthesiologists (JSA) sends annually confidential questionnaires of perioperative mortality and morbidity to Certificated Training Hospitals of JSA. This report is on perioperative mortality and morbidity in 1999 with a special reference to anesthetic methods. Four hundred and sixty-seven hospitals reported the number of cases referred to anesthetic methods and total numbers of cases were 727,723. The incidences of cardiac arrest per 10,000 cases due to all etiology are estimated to be 6.77 cases in average, 5.33 cases in inhalation anesthesia, 34.26 cases in total intravenous anesthesia (TIVA), 5.26 cases in inhalation anesthesia plus epidural or spinal or conduction block, 5.29 cases in TIVA plus epidural or spinal or conduction block, 0.73 cases in spinal with continuous epidural block (CSEA), 2.85 cases in epidural anesthesia, 1.63 cases in spinal anesthesia, 2.53 cases in conduction block and 46.51 cases in other methods. However, the incidences of cardiac arrest per 10,000 cases totally attributable to anesthesia are estimated to be 0.78 case in average, 0.51 case in inhalation anesthesia, 1.35 cases in TIVA, 0.97 case in inhalation anesthesia plus epidural or spinal or conduction block, 1.51 cases in TIVA plus epidural or spinal or conduction block, 0.73 case in CSEA, 1.71 cases in epidural anesthesia, 0.54 case in spinal anesthesia, 2.52 cases in conduction block and 1.08 cases in other methods. The incidences of severe hypotension per 10,000 cases due to all etiology are estimated to be 16.64 cases in average, 13.61 cases in inhalation anesthesia, 100.36 cases in TIVA, 13.32 cases in inhalation anesthesia plus epidural or spinal or conduction block, 9.07 cases in TIVA plus epidural or spinal or conduction block, 3.65 cases in CSEA, 6.26 cases in epidural anesthesia, 7.31 cases in spinal anesthesia, 2.52 cases in conduction block and 28.12 cases in other methods. On the other hand, the incidences of cardiac arrest per 10,000 cases totally attributable to anesthesia are estimated to be 2.40 cases in average, 1.65 cases in inhalation anesthesia, 0.81 cases in TIVA, 3.92 cases in inhalation anesthesia plus epidural or spinal or conduction block, 2.77 cases in TIVA plus epidural or spinal or conduction block, 2.56 cases in CSEA, 3.42 cases in epidural anesthesia, 2.71 cases in spinal anesthesia, zero case in conduction block and zero case in other methods. The incidences of severe hypoxia per 10,000 cases due to all etiology are estimated to be 5.32 cases in average, 6.7 cases in inhalation anesthesia, 9.17 cases in TIVA, 5.16 cases in inhalation anesthesia plus epidural or spinal or conduction block, 4.53 cases in TIVA plus epidural or spinal or conduction block, 2.56 cases in CSEA, zero case in epidural anesthesia, 1.08 cases in spinal anesthesia, zero case in conduction block and 1.08 cases in other methods. On the other hand, the incidences of severe hypoxia per 10,000 cases totally attributable to anesthesia are estimated to be 2.39 cases in average, 3.22 cases in inhalation anesthesia, 2.43 cases in TIVA, 2.26 cases in inhalation anesthesia plus epidural or spinal or conduction block, 2.77 cases in TIVA plus epidural or spinal or conduction block, zero case in CSEA, zero case in epidural anesthesia, 0.54 cases in spinal anesthesia, zero case in conduction block and 1.08 cases in other methods. The mortality rates of cardiac arrest per 10,000 cases due to all etiology are estimated to be 3.56 cases in average, 2.82 cases in inhalation anesthesia, 24.55 cases in TIVA, 1.4 cases in inhalation anesthesia plus epidural or spinal or conduction block, 1.51 cases in TIVA plus epidural or spinal or conduction block, zero cases in CSEA, 0.57 cases in epidural anesthesia, 0.27 cases in spinal anesthesia, zero case in conduction block and 42.18 cases in other methods. On the other hand, the mortality rates of cardiac arrest per 10,000 cases totally attributable to anesthesia are estimated to be 0.08 case in average, 0.09 case in inhalation anesthesia, 0.27 case in TIVA, 0.05 case in inhalation anesthesia plus epidural or spinal or conduction block, zero case in TIVA plus epidural or spinal or conduction block, zero case in CSEA, 0.57 case in epidural anesthesia, zero case in spinal anesthesia, conduction block and other methods. The outcomes of cardiac arrest totally attributable to anesthesia are 70.2% of full recovery without any sequelae, 10.5% of death within 7 days, 1.8% of vegetative state and 17.5% of unknown results while the outcome of critical events including severe hypotension and severe hypoxia totally attributable to anesthesia is 94.9% of full recovery without any sequelae, 0.4% of death within 7 days, 0.2% of vegetative state and 4.5% of unknown results. These results indicate that there are no differences in mortality and morbidity totally attributable to anesthesia among anesthetic methods in 1999 at Certificated Training Hospitals of Japan Society of Anesthesiologists.
日本麻醉医师协会手术室安全委员会每年向该协会的认证培训医院发送围手术期死亡率和发病率的保密调查问卷。本报告是关于1999年围手术期死亡率和发病率的情况,特别提及麻醉方法。467家医院报告了按麻醉方法分类的病例数,病例总数为727,723例。每10,000例所有病因导致的心脏骤停发生率估计平均为6.77例,吸入麻醉为5.33例,全静脉麻醉(TIVA)为34.26例,吸入麻醉加硬膜外或脊髓或传导阻滞为5.26例,TIVA加硬膜外或脊髓或传导阻滞为5.29例,腰麻联合连续硬膜外阻滞(CSEA)为0.73例,硬膜外麻醉为2.85例,腰麻为1.63例,传导阻滞为2.53例,其他方法为46.51例。然而,每10,000例完全归因于麻醉的心脏骤停发生率估计平均为0.78例,吸入麻醉为0.51例,TIVA为1.35例,吸入麻醉加硬膜外或脊髓或传导阻滞为0.97例,TIVA加硬膜外或脊髓或传导阻滞为1.51例,CSEA为0.73例,硬膜外麻醉为1.71例,腰麻为0.54例,传导阻滞为2.52例,其他方法为1.08例。每10,000例所有病因导致的严重低血压发生率估计平均为16.64例,吸入麻醉为13.61例,TIVA为100.36例,吸入麻醉加硬膜外或脊髓或传导阻滞为13.32例,TIVA加硬膜外或脊髓或传导阻滞为9.07例,CSEA为3.65例,硬膜外麻醉为6.26例,腰麻为7.31例,传导阻滞为2.52例,其他方法为28.12例。另一方面,每10,000例完全归因于麻醉的严重低血压发生率估计平均为2.40例,吸入麻醉为1.65例,TIVA为0.81例,吸入麻醉加硬膜外或脊髓或传导阻滞为3.92例,TIVA加硬膜外或脊髓或传导阻滞为2.77例,CSEA为2.56例,硬膜外麻醉为3.42例,腰麻为2.71例,传导阻滞为零例,其他方法为零例。每10,000例所有病因导致的严重低氧发生率估计平均为5.32例,吸入麻醉为6.7例,TIVA为9.17例,吸入麻醉加硬膜外或脊髓或传导阻滞为5.16例,TIVA加硬膜外或脊髓或传导阻滞为4.53例,CSEA为2.56例,硬膜外麻醉为零例,腰麻为1.08例,传导阻滞为零例,其他方法为1.08例。另一方面,每10,000例完全归因于麻醉的严重低氧发生率估计平均为2.39例,吸入麻醉为3.22例,TIVA为2.43例,吸入麻醉加硬膜外或脊髓或传导阻滞为2.26例,TIVA加硬膜外或脊髓或传导阻滞为2.77例,CSEA为零例,硬膜外麻醉为零例,腰麻为0.54例,传导阻滞为零例,其他方法为1.08例。每10,000例所有病因导致的心脏骤停死亡率估计平均为3.56例,吸入麻醉为2.82例,TIVA为24.55例,吸入麻醉加硬膜外或脊髓或传导阻滞为1.4例,TIVA加硬膜外或脊髓或传导阻滞为1.51例,CSEA为零例,硬膜外麻醉为0.57例,腰麻为0.27例,传导阻滞为零例,其他方法为42.18例。另一方面,每10,000例完全归因于麻醉的心脏骤停死亡率估计平均为0.08例,吸入麻醉为0.09例,TIVA为0.27例,吸入麻醉加硬膜外或脊髓或传导阻滞为0.05例,TIVA加硬膜外或脊髓或传导阻滞为零例,CSEA为零例,硬膜外麻醉为0.57例,腰麻为零例,传导阻滞和其他方法为零例。完全归因于麻醉的心脏骤停结果为70.2%完全恢复且无任何后遗症,10.5%在7天内死亡,1.8%处于植物状态,17.5%结果不明,而完全归因于麻醉的包括严重低血压和严重低氧在内的危急事件结果为94.9%完全恢复且无任何后遗症,0.4%在7天内死亡,0.2%处于植物状态,4.5%结果不明。这些结果表明,1999年在日本麻醉医师协会认证培训医院中,各种麻醉方法之间完全归因于麻醉的死亡率和发病率没有差异。