Tatezaki S
Nihon Seikeigeka Gakkai Zasshi. 1979 Jul;53(7):831-46.
Sixty-one patients with osteosarcoma were treated. Twenty-four of these patients were managed with our systematic multi-modal treatment. Overall survival rate was markedly improved chiefly by intensive systemic chemotherapy with multiple drugs, especially adriamycin and high dose methotrexate. Preoperative regional intra-arterial infusion of anti-tumor drugs and fast neutron radiotherapy were employed and it was suggested that fast neutron had a higher relative biological effectiveness and a greater therapeutic gain factor as compared with X-rays. Fast neutron radiotherapy can play a significant role in the very systematic treatment of osteosarcoma and is specifically useful for preservation of the affected limbs.
61例骨肉瘤患者接受了治疗。其中24例患者采用了我们的系统性多模式治疗。总体生存率显著提高，主要得益于多种药物的强化全身化疗，尤其是阿霉素和大剂量甲氨蝶呤。采用了术前区域动脉内抗肿瘤药物灌注和快中子放射治疗，结果表明与X射线相比，快中子具有更高的相对生物效应和更大的治疗增益因子。快中子放射治疗在骨肉瘤的系统性治疗中可发挥重要作用，尤其有助于保肢。
