Peri C V, Shaffrey M E, Farace E, Cooper E, Alves W M, Cooper J B, Young J S, Jane J A
University of Virginia, Charlottesville, VA 22908, USA.
Brain Inj. 2001 Oct;15(10):903-10. doi: 10.1080/02699050110065709.
To determine if electrical stimulation (ES) benefits (waking time, 3-month outcomes) treated coma patients.
Double blind randomized-controlled study.
Ten coma patients; six treatment and four controls, using the 'Respond Select' by EMPI.
Treatment group received radial nerve ES applied in 300 ms intermittent pulses at 40 Hz, 15-20m A 8 hours a day up to 14 days of coma; control group received sham stimulation.
ES group emerged from coma mean 2 days earlier than controls, although this result was not statistically significant. At 3 months post-injury, there was no group difference in Glasgow Outcome Scale, although the ES group had improved function over controls as measured by the FIM/FAM (mean of 114 and 64.5, respectively, n.s.).
These data show an interesting trend, although statistical power was limited in this small pilot study, suggesting the need for a larger trial.
确定电刺激（ES）对接受治疗的昏迷患者是否有益（清醒时间、3个月的预后）。
双盲随机对照研究。
10名昏迷患者；6名治疗组和4名对照组，使用EMPI公司的“Respond Select”。
治疗组接受桡神经电刺激，以40Hz的频率施加300ms的间歇脉冲，电流为15 - 20mA，每天8小时，持续至昏迷14天；对照组接受假刺激。
电刺激组比对照组平均提前2天苏醒，尽管该结果无统计学意义。受伤后3个月，格拉斯哥预后评分无组间差异，尽管通过FIM/FAM测量，电刺激组的功能比对照组有所改善（分别为114和64.5，无统计学意义）。
这些数据显示出一个有趣的趋势，尽管在这项小型初步研究中统计效能有限，这表明需要进行更大规模的试验。
