Meachim G, Fergie I A
J Pathol. 1975 Apr;115(4):231-40. doi: 10.1002/path.1711150408.
The morphology of articular cartilage fibrillation is usually studied in sections cut vertical to the surface. The present study instead concerns the appearances seen when the surface is viewed en face. The study has been made on indian ink preparations of unfixed, hydrated tissue mounted in physiological saline and examined by stereomicroscopy at times 10 while in situ on the bone, and by transmitted light microscopy of tangential surface slices at magnifications up to times 150. The results are consistent with an hypothesis that fibrillation represents mechanically induced focal wear of the tissue. Various sorts of "minimal fibrillation" and other types of surface markings are illustrated. The en face pattern of the cartilage lesions is to some extent influenced by anatomical site, and it is suggested that it is modified by the local biomechanical environment and local character of the cartilage. Some, but not all, of the various patterns show orientation in the sense either of being predominantly unidirectional or of having two major alignments one at right-angles to the other. The differing relationships of this orientation, when present, to the direction of joint movement and to the alignment of the superficial collagen and its tensile strength, are described and discussed.
关节软骨纤维化的形态通常是在垂直于表面切割的切片中进行研究。而本研究关注的是从正面观察表面时所呈现的外观。该研究是在未固定、水化的组织上进行的，将其用印度墨水处理后置于生理盐水中，在原位于骨上时用实体显微镜在10倍放大倍数下观察，并用透射光显微镜对切向表面切片在放大倍数高达150倍时进行观察。结果与一种假说相符，即纤维化代表组织的机械性诱导局灶性磨损。文中展示了各种“微小纤维化”及其他类型的表面标记。软骨损伤的正面模式在一定程度上受解剖部位影响，并且表明它会受到局部生物力学环境和软骨局部特性的改变。各种模式中的一些（但并非全部）在某种意义上呈现出主要为单向或具有两个相互垂直的主要排列方向的取向。描述并讨论了这种取向（若存在）与关节运动方向、与表面胶原排列及其拉伸强度的不同关系。
