Peng J N, Feng X Z, Li G Y, Liang X T
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
Yao Xue Xue Bao. 1997 Dec;32(12):908-13.
Many species of genus Hedyotis (Rubiaceae) were used as folk medicine for treatment of cold, inflammation, cancer and etc. in China. The alcoholic extract of the whole plant of H. chrysotricha showed good hepatoprotective effects. From the alcoholic extract ten iridoids were isolated and their structures were elucidated as: asperuloside (1), scandoside methyl ester (2), asperulosidic acid (3), deacetyl asperulosidic acid (4), loganin (5), deacetyl asperuloside (6), acetyl scandoside methyl ester (7), 6 beta-hydroxy-genipin (8) and two new compounds named hedyoside (9) and 6'-acetylasperuloside (10), by means of chemical and spectral methods.
在中国，许多耳草属（茜草科）植物被用作民间药物来治疗感冒、炎症、癌症等。黄毛耳草全草的乙醇提取物显示出良好的保肝作用。从该乙醇提取物中分离出10种环烯醚萜类化合物，并通过化学和光谱方法阐明了它们的结构，分别为：车叶草苷（1）、车叶草苷甲酯（2）、车叶草苷酸（3）、去乙酰车叶草苷酸（4）、马钱子苷（5）、去乙酰车叶草苷（6）、乙酰车叶草苷甲酯（7）、6β-羟基京尼平（8）以及两个新化合物，分别命名为耳草苷（9）和6'-乙酰车叶草苷（10）。
