Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses.

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作者信息

Koup J R, Greenblatt D J, Jusko W J, Smith T W, Koch-Weser J

出版信息

J Pharmacokinet Biopharm. 1975 Jun;3(3):181-92. doi: 10.1007/BF01067907.

DOI:10.1007/BF01067907

PMID:1159622

Abstract

摘要

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Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses.

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本文引用的文献

The metabolism of tritiated digoxin in renal insufficiency in dogs and man.氚标记地高辛在犬和人肾功能不全时的代谢

J Pharmacol Exp Ther. 1966 Jun;152(3):372-82.

Relationship of the excretion of tritiated digoxin to renal function.氚标记地高辛排泄与肾功能的关系。

Am J Med Sci. 1966 Feb;251(2):133-44. doi: 10.1097/00000441-196602000-00002.

An improved method of digoxin therapy.一种改进的地高辛治疗方法。

Ann Intern Med. 1968 Oct;69(4):703-17. doi: 10.7326/0003-4819-69-4-703.

Relationship of plasma digitoxin and digoxin to cardiac response following intravenous digitalization in man.人体静脉注射洋地黄毒苷和地高辛后血浆洋地黄毒苷和地高辛与心脏反应的关系。

Circulation. 1970 Dec;42(6):1065-72. doi: 10.1161/01.cir.42.6.1065.

Assessment of pharmacokinetic constants from postinfusion blood curves obtained after I.V. infusion.通过静脉输注后获得的输注后血药浓度曲线评估药代动力学常数。

J Pharm Sci. 1970 Jan;59(1):53-5. doi: 10.1002/jps.2600590107.

Digoxin metabolism in obesity.肥胖状态下的地高辛代谢

Circulation. 1971 Nov;44(5):810-4. doi: 10.1161/01.cir.44.5.810.

Effects of change in elimination on varous parameters of the two-compartment open model.消除变化对二室开放模型各参数的影响。

J Pharm Sci. 1972 Aug;61(8):1270-3. doi: 10.1002/jps.2600610820.

Bioavailability and dissolution properties of two commercial digoxin tablets.

J Pharm Sci. 1974 Aug;63(8):1231-4. doi: 10.1002/jps.2600630813.

Renal tubular secretion of digoxin.地高辛的肾小管分泌

Circulation. 1974 Jul;50(1):103-7. doi: 10.1161/01.cir.50.1.103.

Intravenous digoxin as a bioavailability standard: slow infusion and rapid injection.静脉注射地高辛作为生物利用度标准：缓慢输注和快速注射。

Clin Pharmacol Ther. 1974 May;15(5):510-3. doi: 10.1002/cpt1974155510.

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