Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses.

Suppr

超能文献

作者信息

Koup J R, Greenblatt D J, Jusko W J, Smith T W, Koch-Weser J

出版信息

J Pharmacokinet Biopharm. 1975 Jun;3(3):181-92. doi: 10.1007/BF01067907.

DOI:10.1007/BF01067907

PMID:1159622

Abstract

摘要

相似文献

Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses.

J Pharmacokinet Biopharm. 1975 Jun;3(3):181-92. doi: 10.1007/BF01067907.

Comparison of the pharmacokinetic parameters of digoxin and SC4453 a digoxin analogue, following a single bolus i.v. dose and following an infusion preceeded by an i.v. loading dose in the guinea-pig.

J Pharmacol. 1983 Jan-Mar;14(1):9-17.

Dose-independent pharmacokinetics of digoxin in humans.

Am Heart J. 1978 Oct;96(4):507-11. doi: 10.1016/0002-8703(78)90162-x.

Single- and multiple-dose kinetics of intravenous digoxin.

Clin Pharmacol Ther. 1980 Sep;28(3):340-5. doi: 10.1038/clpt.1980.171.

The pharmacokinetics of digoxin in newborn and adult sheep.地高辛在新生和成年绵羊体内的药代动力学。

J Pharmacokinet Biopharm. 1982 Apr;10(2):173-86. doi: 10.1007/BF01062334.

Evidence of nonlinearity in digoxin pharmacokinetics.

J Pharmacokinet Biopharm. 1981 Apr;9(2):147-66. doi: 10.1007/BF01068079.

Effects of amiodarone on oral and intravenous digoxin kinetics in healthy subjects.

J Cardiovasc Pharmacol. 1987 Apr;9(4):385-90. doi: 10.1097/00005344-198704000-00001.

Lack of difference in digoxin urinary excretion with two intravenous infusion rates.

Clin Pharmacol Ther. 1981 Sep;30(3):317-20. doi: 10.1038/clpt.1981.166.

Absorption of digoxin from different oral preparations in normal subjects during steady state.

Clin Pharmacol Ther. 1974 Aug;16(2):310-7. doi: 10.1002/cpt1974162310.

Pharmacokinetics of digoxin and its 4'''-acetyl- and methylderivates in the rat.地高辛及其4'''-乙酰基和甲基衍生物在大鼠体内的药代动力学。

Naunyn Schmiedebergs Arch Pharmacol. 1972;274(2):171-81. doi: 10.1007/BF00501851.

引用本文的文献

Theoretical Examination Seeking Tangible Physical Meanings of Slopes and Intercepts of Plasma Concentration-Time Relationships in Minimal Physiologically Based Pharmacokinetic Models.理论探讨：最小生理基于药代动力学模型中血浆浓度-时间关系的斜率和截距的有形物理意义。

AAPS J. 2023 Jan 26;25(1):19. doi: 10.1208/s12248-022-00779-x.

Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin.转运体基因 ABCB1 的常见 SNPs 组合影响地高辛的口服表观生物利用度，但不影响其肾清除率。

Sci Rep. 2020 Jul 27;10(1):12457. doi: 10.1038/s41598-020-69326-y.

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations.通过将基于生理学的肾脏模型应用于肾功能损害人群来阐明各种因素在洋地黄毒苷肾脏处置中的作用。

J Pharmacol Exp Ther. 2017 Mar;360(3):484-495. doi: 10.1124/jpet.116.237438. Epub 2017 Jan 5.

Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug-Drug Interactions and Co-medication Regimens.克拉霉素、咪达唑仑和地高辛：应用生理药代动力学（PBPK）模型深入了解药物相互作用和联合用药方案。

AAPS J. 2017 Jan;19(1):298-312. doi: 10.1208/s12248-016-0009-9. Epub 2016 Nov 7.

Contemporary Controversies in Digoxin Use in Systolic Heart Failure.收缩性心力衰竭中地高辛使用的当代争议

Curr Heart Fail Rep. 2016 Oct;13(5):197-206. doi: 10.1007/s11897-016-0302-z.

Polypharmacy in the HIV-infected older adult population.老年 HIV 感染者的多种药物治疗。

Clin Interv Aging. 2013;8:749-63. doi: 10.2147/CIA.S37738. Epub 2013 Jun 21.

Altered distribution of digoxin in renal failure--a cause of digoxin toxicity?肾衰竭时地高辛分布改变——地高辛中毒的一个原因？

Br J Clin Pharmacol. 1976 Dec;3(6):1045-51. doi: 10.1111/j.1365-2125.1976.tb00356.x.

Therapeutic drug monitoring of antiarrhythmic drugs.抗心律失常药物的治疗药物监测

Clin Pharmacokinet. 2003;42(7):647-63. doi: 10.2165/00003088-200342070-00004.

Intravenously administered digoxin in patients with acute atrial fibrillation: a population pharmacokinetic/pharmacodynamic analysis based on the Digitalis in Acute Atrial Fibrillation trial.急性心房颤动患者静脉注射地高辛：基于急性心房颤动地高辛试验的群体药代动力学/药效学分析

Eur J Clin Pharmacol. 2003 Mar;58(11):747-55. doi: 10.1007/s00228-002-0553-3. Epub 2003 Feb 19.

Comparative bioequivalence study of different brands of acetyl salicylic acid in human volunteers.不同品牌乙酰水杨酸在人体志愿者中的比较生物等效性研究。

Eur J Drug Metab Pharmacokinet. 1993 Jul-Sep;18(3):251-3. doi: 10.1007/BF03188804.

本文引用的文献

The metabolism of tritiated digoxin in renal insufficiency in dogs and man.氚标记地高辛在犬和人肾功能不全时的代谢

J Pharmacol Exp Ther. 1966 Jun;152(3):372-82.

Relationship of the excretion of tritiated digoxin to renal function.氚标记地高辛排泄与肾功能的关系。

Am J Med Sci. 1966 Feb;251(2):133-44. doi: 10.1097/00000441-196602000-00002.

An improved method of digoxin therapy.一种改进的地高辛治疗方法。

Ann Intern Med. 1968 Oct;69(4):703-17. doi: 10.7326/0003-4819-69-4-703.

Relationship of plasma digitoxin and digoxin to cardiac response following intravenous digitalization in man.人体静脉注射洋地黄毒苷和地高辛后血浆洋地黄毒苷和地高辛与心脏反应的关系。

Circulation. 1970 Dec;42(6):1065-72. doi: 10.1161/01.cir.42.6.1065.

Assessment of pharmacokinetic constants from postinfusion blood curves obtained after I.V. infusion.通过静脉输注后获得的输注后血药浓度曲线评估药代动力学常数。

J Pharm Sci. 1970 Jan;59(1):53-5. doi: 10.1002/jps.2600590107.

Digoxin metabolism in obesity.肥胖状态下的地高辛代谢

Circulation. 1971 Nov;44(5):810-4. doi: 10.1161/01.cir.44.5.810.

Effects of change in elimination on varous parameters of the two-compartment open model.消除变化对二室开放模型各参数的影响。

J Pharm Sci. 1972 Aug;61(8):1270-3. doi: 10.1002/jps.2600610820.

Bioavailability and dissolution properties of two commercial digoxin tablets.

J Pharm Sci. 1974 Aug;63(8):1231-4. doi: 10.1002/jps.2600630813.

Renal tubular secretion of digoxin.地高辛的肾小管分泌

Circulation. 1974 Jul;50(1):103-7. doi: 10.1161/01.cir.50.1.103.

Intravenous digoxin as a bioavailability standard: slow infusion and rapid injection.静脉注射地高辛作为生物利用度标准：缓慢输注和快速注射。

Clin Pharmacol Ther. 1974 May;15(5):510-3. doi: 10.1002/cpt1974155510.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验