[大蒜素对体外培养兔主动脉平滑肌细胞增殖的影响]

[The effects of allitridum on the proliferation of rabbit aortic smooth muscle cells in vitro].

作者信息

Li Z, Li G, Huang C, Xu J, Jiang H

机构信息

Department of Cardiology, First Affiliated Hospital of Hubei Medical University, Wuhan 430060.

出版信息

Zhongguo Zhong Yao Za Zhi. 1998 Feb;23(2):109-11, inside back cover.

PMID:11596259

Abstract

The effects of allitridum on the proliferation of cultured rabbit aortic smooth muscle cells (SMC) were studied with SMC incorporation data of 3H-thymidine(3H-TdR) and contents of superoxide dismutase(SOD), lipid peroxide(LPO), prostacyclin(PGI2) and cyclic adenosine monophosphate(cAMP) in medium. The results showed that allitridum could inhibit SMC proliferation by increasing SOD activity, decreasing LPO, raising PGI2 and cAMP(all P < 0.05-0.01), and the inhibitory action was accompanied by the dose-effect relation.

摘要

利用3H-胸腺嘧啶核苷（3H-TdR）掺入法检测培养的兔主动脉平滑肌细胞（SMC）增殖情况，并检测培养基中超氧化物歧化酶（SOD）、脂质过氧化物（LPO）、前列环素（PGI2）和环磷酸腺苷（cAMP）含量，研究大蒜素对兔主动脉平滑肌细胞增殖的影响。结果显示，大蒜素可通过提高SOD活性、降低LPO、升高PGI2和cAMP水平来抑制SMC增殖（均P<0.05-0.01），且抑制作用呈剂量效应关系。