卡托普利对主动脉平滑肌细胞增殖的影响。
Effect of captopril on proliferation of aortic smooth muscle cells.
作者信息
Xiong Y L, Zhao H Y
机构信息
Department of Medicine, Tongji Hospital, Tongji Medical University, Wuhan, China.
出版信息
Zhongguo Yao Li Xue Bao. 1996 Nov;17(6):503-6.
AIM
To study the effect of captopril (Cap) on proliferation of smooth muscle cells (SMC).
METHODS
Proliferation of cultured porcine aortic SMC was promoted by hyperlipidemic sera (HLS).
RESULTS
Cap (0.2 mg.L-1) remarkably reduced [3H]thymidine ([3H]TdR) incorporation, inhibited DNA synthesis and proliferation of SMC, and lessened morphological changes caused by HLS. After administration of Cap, malondialdehyde (MDA) content and plasminogen activator inhibitor (PAI) activity were reduced, 6-keto-PGF1 alpha and cAMP contents were obviously increased (P < 0.05-0.01).
CONCLUSION
Cap inhibited the proliferation of SMC, associated with MDA, PAI, 6-keto-PGF1 alpha and cAMP.
目的
研究卡托普利（Cap）对平滑肌细胞（SMC）增殖的影响。
方法
用高脂血清（HLS）促进培养的猪主动脉SMC增殖。
结果
卡托普利（0.2mg.L-1）显著降低[3H]胸腺嘧啶核苷（[3H]TdR）掺入量，抑制SMC的DNA合成和增殖，并减轻HLS引起的形态学变化。给予卡托普利后，丙二醛（MDA）含量和纤溶酶原激活物抑制剂（PAI）活性降低，6-酮-前列腺素F1α和环磷酸腺苷（cAMP）含量明显增加（P<0.05-0.01）。
结论
卡托普利抑制SMC增殖，与MDA、PAI、6-酮-前列腺素F1α和cAMP有关。
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