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[知母中氧杂蒽酮苷的分离与结构鉴定]

[Isolation and structure determination of xanthone glycosides of Anemarrhena asphodeloides].

作者信息

Hong Y F, Han G Y, Guo X M

机构信息

Research Laboratory of Natural and Synthetic Drugs, College of Pharmacy, Second Military Medical University, Shanghai 200433.

出版信息

Yao Xue Xue Bao. 1997 Jun;32(6):473-5.

PMID:11596333
Abstract

Xilingzhimu, the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae), has been prescribed as antipyretic, anti-inflammatory, diuretic and hypoglycemic agents in Chinese traditional medicine. In this paper, two xanthone glycosides I and II, were isolated from Xilingzhimu by conventional method. The structures of I and II were identified on the basis of chemical reactions and UV, IR, 1HNMR, 13CNMR and DEPT. Compound I was identified as mangiferin and II is a new compound, named neomangiferin. Its structure is 7-O-beta-D-glucopyranosyl-mangiferin.

摘要

知母为百合科植物知母(Anemarrhena asphodeloides Bunge)的根茎,在传统中药中被用作解热、抗炎、利尿和降血糖药物。本文采用常规方法从知母中分离得到两种氧杂蒽酮糖苷I和II。通过化学反应以及紫外光谱(UV)、红外光谱(IR)、核磁共振氢谱(1HNMR)、核磁共振碳谱(13CNMR)和无畸变极化转移增强法(DEPT)对I和II的结构进行了鉴定。化合物I被鉴定为芒果苷,化合物II是一种新化合物,命名为新芒果苷。其结构为7 - O - β - D - 吡喃葡萄糖基芒果苷。

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Quantification of neomangiferin in rat plasma by liquid chromatography-tandem mass spectrometry and its application to bioavailability study.液相色谱-串联质谱法测定大鼠血浆中新芒果苷含量及其在生物利用度研究中的应用
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