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可立克复方氨酚烷胺片滥用:中毒控制中心记录的病例

Abuse of Coricidin HBP cough & cold tablets: episodes recorded by a poison center.

作者信息

Banerji S, Anderson I B

机构信息

University of California, San Francisco, California Poison Control System, San Francisco Division, USA.

出版信息

Am J Health Syst Pharm. 2001 Oct 1;58(19):1811-4. doi: 10.1093/ajhp/58.19.1811.

Abstract

Cases involving ingestion of a dextromethorphan-containing product recorded at a poison control center were studied. A retrospective review of all consultations involving the ingestion of Coricidin HBP Cough & Cold tablets recorded by the California Poison Control System was conducted for the period from January 1 to October 1, 2000. Computerized charts on the consultations were reviewed to obtain data on patient age and sex, number of tablets taken, reason for tablet ingestion, symptoms, treatment, disposition, and outcome. A total of 92 charts (for 92 patients) documenting Coricidin HBP Cough & Cold tablet ingestion were reviewed. The reason for tablet ingestion was classified as abuse in 65 patients (71%), a suicide attempt in 8 (9%), misuse in 1 (1%), malicious administration in 1 (1%), and normal use (but with an adverse drug reaction) in 1 (1%); 16 patients (17%) consumed the tablets for an unknown reason. The 92 patients comprised 42 males and 50 females. Among all patients, 78 (85%) were 13-17 years old, and among those classified as having abusive intent, 58 (89%) were in the same age range. The most commonly reported signs and symptoms associated with ingestion were tachycardia (50 patients), hypertension (29), lethargy (40), mydriasis (20), agitation (15), ataxia or dizziness (20), and vomiting (9). Sixty-one patients (66%) had some alteration in mental status. Fifty-six (61%) were treated in the emergency department; 11 (12%) were admitted. All patients recovered completely. Information on the ingestion of Coricidin HBP Cough & Cold tablets recorded at a poison control center indicated a high rate of abuse of the product among teenagers.

摘要

对在一家毒物控制中心记录的涉及摄入含右美沙芬产品的病例进行了研究。对加利福尼亚毒物控制系统记录的2000年1月1日至10月1日期间所有涉及摄入科瑞亭高效咳嗽感冒片的咨询进行了回顾性分析。查阅了咨询的计算机化图表,以获取患者年龄和性别、服用片数、服药原因、症状、治疗、处置和结果等数据。共查阅了92份记录科瑞亭高效咳嗽感冒片摄入情况的图表(涉及92名患者)。服药原因分类如下:65名患者(71%)为滥用,8名(9%)为自杀未遂,1名(1%)为误用,1名(1%)为恶意投药,1名(1%)为正常使用(但有药物不良反应);16名患者(17%)服药原因不明。92名患者中,男性42名,女性50名。所有患者中,78名(85%)年龄在13 - 17岁,在被归类为有滥用意图的患者中,58名(89%)在同一年龄段。与摄入相关的最常见报告体征和症状为心动过速(50名患者)、高血压(29名)、嗜睡(40名)、瞳孔散大(20名)、烦躁不安(15名)、共济失调或头晕(20名)以及呕吐(9名)。61名患者(66%)有精神状态改变。56名(61%)在急诊科接受治疗;11名(12%)入院。所有患者均完全康复。在毒物控制中心记录的关于科瑞亭高效咳嗽感冒片摄入的信息表明,该产品在青少年中滥用率很高。

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