Baker S David, Borys Douglas J
Texas Poison Center Network, Scott & White Clinic and Memorial Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University System Health Science Center College of Medicine, Temple 76508, USA.
Vet Hum Toxicol. 2002 Jun;44(3):169-71.
Coricidin products seemed to be one of the over-the-counter medications being reportedly abused by adolescents, as observed from the Texas Poison Center Network data. This retrospective chart review investigated the occurrence of abuse, developed a patient profile, and defined the clinical effects resulting from the abuse of Coricidin products. Data collected from the Texas Poison Center Network Toxic Exposure Surveillance System database included human exposures between 1998 and 1999, patients > or = 10y old, intentional use or abuse, and single substance ingestion of I of the tablet formulations of Coricidin. Thirty-three cases from 1998 and 59 cases from 1999 were reviewed. Of these cases, 85% met the inclusion criteria. Of the 7 medications searched, only 4 substances were coded for: Coricidin D, Coricidin D (long acting), Coricidin D (cold, flu & sinus) and Coriciding HBP. These contain a combination of dextromethorphan hydrobromide, chlorpheniramine maleate, phenylpropanolamine hydrochloride, and acetaminophen. Of the 78 cases, 63% were male and 38% were female. The mean age was 14.67 years, 77% being between 13 to 17 years old. Eighteen different symptoms were reported: tachycardia 50%, somnolence 24.4%, mydriasis and hypertension 16.7%, agitation 12.8%, disorientation 10.3%, slurred speech 9%, ataxia 6.4%, vomiting 5.1%, dry mouth and hallucinations 3.9%, tremor 2.6%, and headache, dizziness, syncope, seizure, chest pain, and nystagmus each 1.3%; 12.8% of the calls originated from the school nurse. The incidence of abuse reported increased 60% from 1998 to 1999. This worrisome trend suggests increased abuse of these products.
从得克萨斯州中毒控制中心网络的数据来看，科立停产品似乎是据报道被青少年滥用的非处方药物之一。这项回顾性图表审查调查了滥用情况，建立了患者档案，并明确了滥用科立停产品所产生的临床影响。从得克萨斯州中毒控制中心网络中毒暴露监测系统数据库收集的数据包括1998年至1999年间的人体暴露情况、年龄大于或等于10岁的患者、故意使用或滥用情况以及单次摄入科立停片剂配方中的一种。对1998年的33例病例和1999年的59例病例进行了审查。在这些病例中，85%符合纳入标准。在所搜索的7种药物中，只有4种物质有编码：科立停D、长效科立停D、科立停D（感冒、流感和鼻窦炎）以及科立停HBP。这些产品含有氢溴酸右美沙芬、马来酸氯苯那敏、盐酸苯丙醇胺和对乙酰氨基酚的组合。在这78例病例中，63%为男性，38%为女性。平均年龄为14.67岁，77%在13至17岁之间。报告了18种不同症状：心动过速50%、嗜睡24.4%、瞳孔散大和高血压16.7%、激动12.8%、定向障碍10.3%、言语不清9%、共济失调6.4%、呕吐5.1%、口干和幻觉3.9%、震颤2.6%，以及头痛、头晕、晕厥、癫痫发作、胸痛和眼球震颤各1.3%；12.8%的呼叫来自学校护士。1998年至1999年报告的滥用发生率增加了60%。这种令人担忧的趋势表明这些产品的滥用情况有所增加。
