居住在炼油厂区域的棉鼠（刚毛囊鼠）主要组织相容性复合体的遗传多样性
Genetic diversity of the major histocompatibility complex of cotton rats (Sigmodon hispidus) inhabiting an oil refinery complex.
作者信息
Pfau R S, McBee K, Van Den Bussche R A
机构信息
Department of Zoology and Collection of Vertebrates, Oklahoma State University, Stillwater 74078, USA.
出版信息
Environ Toxicol Chem. 2001 Oct;20(10):2224-8.
We examined genetic diversity of an immune-response gene within the major histocompatibility complex in cotton rats (Sigmodon hispidus) inhabiting an oil refinery complex. Genetic diversity of MHC-DQA exon-2 was examined within and among contaminated and noncontaminated reference grids. The level of gene diversity within contaminated grids (0.748) was lower than within reference grids (0.818), but the difference was not statistically significant (p > 0.5). Analysis of molecular variance, pairwise FST values, and hierarchical clustering failed to reveal population genetic structure related to contamination. Results of this study indicate either that the level of contaminant-induced selection is insignificant at this major histocompatibility complex (MHC) locus or that gene flow from surrounding areas has obliterated the effects of selection.
我们研究了居住在炼油厂区域的棉鼠（棉鼠属）主要组织相容性复合体中一个免疫反应基因的遗传多样性。在受污染和未受污染的参考网格内及之间，检测了MHC - DQA外显子2的遗传多样性。受污染网格内的基因多样性水平（0.748）低于参考网格内的（0.818），但差异无统计学意义（p > 0.5）。分子方差分析、成对FST值分析和层次聚类均未揭示与污染相关的种群遗传结构。本研究结果表明，在这个主要组织相容性复合体（MHC）位点上，污染物诱导的选择水平要么微不足道，要么来自周边地区的基因流动消除了选择的影响。
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