Paranjpe M G, Chandra A M, Qualls C W, McMurry S T, Rohrer M D, Whaley M M, Lochmiller R L, McBee K
Department of Veterinary Pathology, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
Toxicol Pathol. 1994 Nov-Dec;22(6):569-78. doi: 10.1177/019262339402200601.
We have developed an in situ mammalian model for evaluating environmental contamination using wild cotton rats. In a series of experiments, 200 male cotton rats were captured during 4 collection periods (spring 1991 = 35; fall 1991 = 60; spring 1992 = 53; fall 1992 = 52). A total of 103 of these cotton rats were captured from control sites, and the remaining 97 were captured from an abandoned oil refinery. All sites were located in the vicinity of Cyril, Oklahoma. There were alterations in the incisors of cotton rats captured from the refinery site. Normal color of cotton rat incisors is deep yellow-orange, which is imparted by a pigment normally produced by ameloblasts. Grossly, the upper incisors of 37 of 97 rats and lower incisors of 54 of 97 rats were affected. The affected incisors were white, chalky, and thin with striations and erosions of the enamel. Microscopic examination revealed that there were dysplastic and necrotic changes in the ameloblasts. The bone fluoride levels were significantly higher in rats captured from the refinery as compared to the rats captured from the control sites.
我们已经开发出一种利用野生棉鼠评估环境污染的原位哺乳动物模型。在一系列实验中，在4个采集期捕获了200只雄性棉鼠（1991年春季 = 35只；1991年秋季 = 60只；1992年春季 = 53只；1992年秋季 = 52只）。其中共有103只棉鼠从对照地点捕获，其余97只从一座废弃炼油厂捕获。所有地点都位于俄克拉何马州西里尔附近。从炼油厂地点捕获的棉鼠的门齿出现了变化。棉鼠门齿的正常颜色是深黄橙色，这是由成釉细胞正常产生的一种色素赋予的。大体上，97只大鼠中有37只的上门齿和97只中有54只的下门齿受到影响。受影响的门齿呈白色、垩状，且薄，有釉质条纹和侵蚀。显微镜检查显示，成釉细胞有发育异常和坏死变化。与从对照地点捕获的大鼠相比，从炼油厂捕获的大鼠的骨氟水平显著更高。
