Synthesis and hypoglycemic activity of phenacyltriphenylphosphoranes and phosphonium salts.
作者信息
Blank B, DiTullio N W, Deviney L, Roberts J T, Saunders H L
出版信息
J Med Chem. 1975 Sep;18(9):952-4. doi: 10.1021/jm00243a021.
PMID:1159720
Abstract
Phenacyl-riphenylphosphorane (1a) and several analogs substituted in the meta position of the phenacyl group lowered blood glucose levels in 48-hr fasted rats. The corresponding phosphonium salts had comparable hypoglycemic activity. Two compounds (1a and 1b) were also hypoglycemic in fed rats, but hypoglycemia could not be elicited in another species.
摘要
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