Blank B, DiTullio N W, Deviney L, Roberts J T, Saunders H L
J Med Chem. 1975 Sep;18(9):952-4. doi: 10.1021/jm00243a021.
Phenacyl-riphenylphosphorane (1a) and several analogs substituted in the meta position of the phenacyl group lowered blood glucose levels in 48-hr fasted rats. The corresponding phosphonium salts had comparable hypoglycemic activity. Two compounds (1a and 1b) were also hypoglycemic in fed rats, but hypoglycemia could not be elicited in another species.
