Hastings M M, Zeman F J
J Nutr. 1979 Nov;109(11):1925-33. doi: 10.1093/jn/109.11.1925.
Thyroxine (T4) and triiodothyronine (T3) concentrations in the plasma and their metabolic clearance and production rates were studied in pregnant protein-deficient and food-restricted rats on the 20th day of gestation. Total T3 levels in the plasma were significantly reduced in malnourished dams, with those of food-restricted dams being consistently lower than those of protein-deficient dams. There were no changes in plasma total T4 concentrations as a result of dietary treatment. Unbound T4 and T3 in the plasma were significantly reduced in both protein-deficient and food-restricted dams. Maternal protein deficiency significantly lowered fetal T4, whereras food restriction caused an elevation. Metabolic clearance rates of T3 and T4 and production rate of T4 were unaffected by diet, while the production rate of T3 was significantly increased in protein deficient dams. Thyroxine to triiodothyronine ratios in malnourished dams were elevated suggesting depressed peripheral conversion of T4 to T3. Alternative factors which may lead to these effects are discussed.
在妊娠第20天，对蛋白质缺乏和食物受限的怀孕大鼠的血浆甲状腺素（T4）和三碘甲状腺原氨酸（T3）浓度及其代谢清除率和生成率进行了研究。营养不良的母鼠血浆中总T3水平显著降低，食物受限母鼠的总T3水平始终低于蛋白质缺乏母鼠。饮食处理对血浆总T4浓度没有影响。蛋白质缺乏和食物受限的母鼠血浆中游离T4和T3均显著降低。母体蛋白质缺乏显著降低了胎儿T4水平，而食物限制则导致胎儿T4水平升高。T3和T4的代谢清除率以及T4的生成率不受饮食影响，而蛋白质缺乏母鼠的T3生成率显著增加。营养不良母鼠的甲状腺素与三碘甲状腺原氨酸比值升高，表明T4向T3的外周转化受到抑制。文中讨论了可能导致这些影响的其他因素。
