de Mello M A, Oliveira-Filho R M, Cury L, Valle L B
Departamento de Educação Física, Universidade Estadual Paulista, Rio Claro, Brazil.
Ann Nutr Metab. 1989;33(3):181-7. doi: 10.1159/000177535.
In order to evaluate some factors likely to be involved in the maternal and fetal growth impairment due to alimentary protein deficiency, the circulating levels of triiodothyronine (T3) and thyroxine (T4) were studied in 4 young (45-day-old) female rat groups: control and malnourished, both nonpregnant and pregnant; similarly scheduled groups were studied using adult (100-day-old) rats. Circulating levels of T4 were higher in nonpregnant, malnourished young rats than in their corresponding controls. T3 levels were higher in young malnourished animals and lower in adult malnourished animals, nonpregnant or pregnant, as compared to controls. Pups from young malnourished mothers showed significantly lower birth weights than those from controls. The present results suggest that there are age differences in thyroid function, as affected by protein-calorie malnutrition in pregnant and nonpregnant rats. On the other hand, the circulating thyroid hormone levels were not importantly affected by the mother dietary protein restriction under our experimental conditions.
为了评估一些可能与因膳食蛋白质缺乏导致的母婴生长发育受损有关的因素，对4组45日龄的年轻雌性大鼠进行了研究，测定了它们血液中三碘甲状腺原氨酸（T3）和甲状腺素（T4）的水平：对照组和营养不良组，包括未怀孕和怀孕的；对同样安排的成年（100日龄）大鼠组也进行了研究。未怀孕的营养不良年轻大鼠的T4循环水平高于相应的对照组。与对照组相比，年轻营养不良动物的T3水平较高，而成年营养不良动物（无论未怀孕还是怀孕）的T3水平较低。来自年轻营养不良母亲的幼崽出生体重明显低于对照组。目前的结果表明，怀孕和未怀孕大鼠的甲状腺功能存在年龄差异，这种差异受蛋白质-热量营养不良的影响。另一方面，在我们的实验条件下，母亲的饮食蛋白质限制对循环甲状腺激素水平没有重要影响。
