Di Costanzo A, Di Salle F, Santoro L, Bonavita V, Tedeschi G
Institute of Neurological Sciences, Second University of Naples, Italy.
Eur Neurol. 2001;46(3):131-9. doi: 10.1159/000050786.
To study the frequency, extent and significance of dilated Virchow-Robin spaces (VRSs) in dystrophia myotonica (DM), we evaluated the cranial magnetic resonance imaging (MRI) of 41 patients with the adult form of DM and 41 healthy controls. Dilated VRSs and white matter lesions (WMLs) were rated according to semiquantitative methods. Convexity VRSs were more frequent (68 vs. 34%; p < 0.01) and severer (median scores: 4 vs. 0; p < 0.01) in DM patients than in controls, while lenticulostriate VRSs did not show significant differences in frequency (83 vs. 70%; p > 0.05) and severity (median scores: 4 vs. 3; p > 0.05). WMLs were more frequent (66 vs. 22%; p < 0.01) and severer (median scores: 5 vs. 0; p < 0.01) in patients. Disease duration was negatively correlated with convexity VRSs and positively with lobar (centrum semiovale) WML scores. Dilated convexity VRSs might be one of the initial findings in cranial MRI of DM, preceding the appearance of lobar WMLs.
为研究强直性肌营养不良症（DM）中扩张型血管周围间隙（VRSs）的频率、范围及意义，我们评估了41例成年型DM患者及41名健康对照者的头颅磁共振成像（MRI）。根据半定量方法对扩张型VRSs和白质病变（WMLs）进行评分。与对照组相比，DM患者的凸面VRSs更为常见（68%对34%；p<0.01）且更严重（中位数评分：4对0；p<0.01），而豆纹VRSs在频率（83%对70%；p>0.05）和严重程度（中位数评分：4对3；p>0.05）方面无显著差异。患者的WMLs更为常见（66%对22%；p<0.01）且更严重（中位数评分：5对0；p<0.01）。病程与凸面VRSs呈负相关，与脑叶（半卵圆中心）WML评分呈正相关。扩张型凸面VRSs可能是DM头颅MRI的早期表现之一，早于脑叶WMLs的出现。
