Oshimura M, Sandberg A A
J Urol. 1975 Aug;114(2):249-50. doi: 10.1016/s0022-5347(17)66999-4.
In a continuing search for karyotypic changes characterizing various human cancers we have examined in detail with Q and G banding techniques the chromosomal constitution of a metastatic cancer of the prostate. The results obtained with these techniques present not only what is to our knowledge the first description of the chromosome constitution in cancer of the prostate but also the first observation of an isochromosome 17 marker in a cancerous state other than a blood disease. Only further studies on the precise identification of individual chromosomes in other cancers will reveal the significance of this marker in human cancer.
在持续探索表征各种人类癌症的核型变化过程中，我们运用Q带和G带技术，详细检查了一例前列腺转移性癌的染色体组成。这些技术所获得的结果不仅是据我们所知对前列腺癌染色体组成的首次描述，也是在除血液疾病之外的癌状态下首次观察到17号等臂染色体标记。只有对其他癌症中单个染色体的精确识别进行进一步研究，才能揭示该标记在人类癌症中的意义。
