Kropacheva E S, Titaeva E V, Dobrovol'skiĭ A B, Komarov A L, Karpov Iu A, Panchenko E P
Ter Arkh. 2001;73(8):16-9.
To analyze efficiency of semi-quantitative fast D-dimer test in diagnosis of deep vein thrombosis (DVT) and thromboembolism of pulmonary artery (TPA).
The study enrolled 42 patients (26 males and 16 females) aged 25 to 86 years. 30 and 12 of them were suspected to have DVT and TPA, respectively. DVT was verified at ultrasound dopplerography and radionuclide phlebography in 16 of 30 suspects. TPA was verified by x-ray, perfusion scintigraphy of the lungs and at autopsy (one case) in 7 of 12 suspects. D-dimer levels in the blood were measured by latex parts agglutination reaction. The parts were covered with monoclonal antibodies to D-dimer. The reagents were provided by the kit Roche/Diagnostica Stago.
The D-dimer test was positive in 20 of 23 DVT patients and negative in 3 cases (13%). Of 19 patients with rejected diagnosis of DVT/TPA the test was negative in 17(89.4%) and positive in 2 patients (10.6%). Thus, sensitivity and specificity of the D-dimer test was 87% and 89.4%, respectively.
High sensitivity of the test allows to use it in screening for DVT/TPA. Negative D-dimer test rejects DVT, while positive test needs verification by other methods.
分析半定量快速D-二聚体检测在诊断深静脉血栓形成（DVT）和肺动脉血栓栓塞（TPA）中的效率。
本研究纳入了42例年龄在25至86岁之间的患者（26例男性和16例女性）。其中30例和12例分别疑似患有DVT和TPA。30例疑似DVT患者中，16例经超声多普勒检查和放射性核素静脉造影证实患有DVT。12例疑似TPA患者中，7例经X线、肺灌注闪烁扫描及尸检（1例）证实患有TPA。采用乳胶颗粒凝集反应检测血液中的D-二聚体水平。颗粒表面覆盖有针对D-二聚体的单克隆抗体。试剂由罗氏/诊断斯塔戈试剂盒提供。
23例DVT患者中，20例D-二聚体检测呈阳性，3例呈阴性（13%）。19例排除DVT/TPA诊断的患者中，17例检测呈阴性（89.4%），2例呈阳性（10.6%）。因此，D-二聚体检测的敏感性和特异性分别为87%和89.4%。
该检测具有高敏感性，可用于DVT/TPA的筛查。D-二聚体检测阴性可排除DVT，而阳性结果则需要通过其他方法进行验证。
