Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones.
作者信息
Ochel H J, Eichhorn K, Gademann G
机构信息
Medical Faculty, Clinic for Radiation Therapy, Otto-von-Guericke-University, Magdeburg, Germany.
出版信息
Cell Stress Chaperones. 2001 Apr;6(2):105-12. doi: 10.1379/1466-1268(2001)006<0105:gtpoac>2.0.co;2.
Abstract
摘要
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本文引用的文献
1
Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin.热休克蛋白90（hsp90）特异性化合物格尔德霉素可诱导异源三聚体Gα(o)亚基通过蛋白酶体途径降解。
J Biol Chem. 2000 Jan 21;275(3):1565-9. doi: 10.1074/jbc.275.3.1565.
2
Geldanamycin induces cell cycle arrest in K562 erythroleukemic cells.格尔德霉素可诱导K562红白血病细胞发生细胞周期阻滞。
IUBMB Life. 1999 Oct;48(4):425-8. doi: 10.1080/713803539.
3
The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association.泛素化受损导致突变型p53的稳定机制：野生型p53功能丧失与hsp90关联
Oncogene. 1999 Oct 28;18(44):6037-49. doi: 10.1038/sj.onc.1202978.
4
A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90.90 kDa分子伴侣热休克蛋白90（HSP90）一种新的伴侣活性降低机制。
Biochem J. 1999 Nov 1;343 Pt 3(Pt 3):697-703.
5
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.萝卜硫素与分子伴侣热休克蛋白90家族成员的相互作用。
Mol Endocrinol. 1999 Sep;13(9):1435-48. doi: 10.1210/mend.13.9.0339.
6
Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases.苯醌型安莎霉素（除莠霉素A和格尔德霉素）干扰生长因子受体酪氨酸激酶的成熟过程。
Cell Stress Chaperones. 1999 Mar;4(1):19-28. doi: 10.1006/csac.1998.0115.
7
8
Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide.热休克蛋白90介导紫杉醇和细菌脂多糖对巨噬细胞的激活作用。
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5645-50. doi: 10.1073/pnas.96.10.5645.
9
Functional requirement of p23 and Hsp90 in telomerase complexes.端粒酶复合物中p23和Hsp90的功能需求。
Genes Dev. 1999 Apr 1;13(7):817-26. doi: 10.1101/gad.13.7.817.
10
The charged region of Hsp90 modulates the function of the N-terminal domain.热休克蛋白90（Hsp90）的带电区域调节N端结构域的功能。
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1297-302. doi: 10.1073/pnas.96.4.1297.
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