Frank E, Judge R
Department of Psychiatry, School of Medicine, University of Pittsburgh, Penn 15213, USA.
J Clin Psychiatry. 2001;62 Suppl 22:10-5.
Depression is a treatable disorder, although it often requires long-term therapy. To aid physicians in the effective long-term management of depression, treatment guidelines have been established by a number of organizations with minimum treatment duration recommendations. Unfortunately, numerous studies document a significant disparity between these recommendations and clinical practice realities. In particular, studies have shown that fewer than half of treated patients receive the recommended duration of 6 months of continuation therapy. Other clinical practice studies have reported that early discontinuation from therapy is associated with a substantial increase in the risk of relapse or recurrence. Long-term treatment of depression in clinical practice settings may benefit from a closer approximation to the conditions found in clinical trial settings.
抑郁症是一种可治疗的疾病，尽管通常需要长期治疗。为帮助医生对抑郁症进行有效的长期管理，许多组织已制定了治疗指南，并给出了最短治疗时长建议。遗憾的是，大量研究表明这些建议与临床实际情况存在显著差异。特别是，研究显示接受治疗的患者中，不到一半的人接受了建议的6个月持续治疗时长。其他临床实践研究报告称，过早停药与复发风险大幅增加有关。在临床实践环境中对抑郁症进行长期治疗，若能更接近临床试验环境中的条件，可能会有所助益。
