Burchard G D, Browne E N, Sievertsen J, May J, Meyer C G
Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Acta Trop. 2001 Oct 22;80(2):103-9. doi: 10.1016/s0001-706x(01)00157-7.
The occurrence of enlarged spleens and its age distribution has long been used as a crude measure to estimate malaria endemicity in cross-sectional surveys. Spleen size, however, is influenced by several variables that should be considered if they are observed in a population under study. We hypothesized that spleen indices are dependent on distinct red blood cell polymorphisms. Accordingly, we expected a lower prevalence of splenomegaly among patients with the sickle-cell trait (HbAS), HbAC trait and G6PD deficiency than in patients without red cell disorders, possibly due to the lower incidence of malaria attacks in these individuals. In our survey, however, spleen rates and sizes did not differ significantly between HbAA-, HbAS- and HbAC-positive individuals. Furthermore, enlargement of spleens was found at similar frequencies in persons with and without glucose-6-phosphate-dehydrogenase (G6PD)-deficiency (G6PD-A(-)).
在横断面调查中，脾脏肿大的发生率及其年龄分布长期以来一直被用作估计疟疾流行程度的粗略指标。然而，脾脏大小受几个变量影响，如果在研究人群中观察到这些变量，就应该予以考虑。我们假设脾脏指数取决于不同的红细胞多态性。因此，我们预计镰状细胞性状（HbAS）、HbAC性状和葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症患者的脾肿大患病率低于无红细胞疾病的患者，这可能是由于这些个体疟疾发作的发生率较低。然而，在我们的调查中，HbAA、HbAS和HbAC阳性个体之间的脾脏发生率和大小没有显著差异。此外，在有和没有葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症（G6PD-A(-)）的人群中，脾脏肿大的发现频率相似。
