Caldas A J, Silva D R, Pereira C C, Nunes P M, Silva B P, Silva A A, Barral A, Costa J M
Departamento de Enfermagem, Universidade Federal do Maranhão, São Luís, MA, Brasil.
Rev Soc Bras Med Trop. 2001 Sep-Oct;34(5):445-51. doi: 10.1590/s0037-86822001000500007.
A prospective study was undertaken in 648 children with less than 6 years of age in the municipality of Raposa, Maranhão, Brazil, from June 1997 to June 1998, to evaluate the characteristics of the infection by L.(L.)chagasi and verify if there is an association between malnutrition and asymptomatic infection. A standardized questionnaire was used containing socioeconomic, environmental and behavioral data. Montenegro skin reaction (IDRM) with L. amazonensis and Enzyme Linked Immunosorbent Assay (ELISA) test to detect infection, and anthropometric examination were performed. Initial and final prevalence and incidence of infection were 18.6%, 20.6% and 10.8% as measured by IDRM and 13.5%, 34.4% and 28% according to ELISA. The prevalence of chronic malnutrition was 26%. No association was detected between malnutrition and asymptomatic infection by L. (L.) chagasi. More effective control measures are needed in these areas since asymptomatic infection seems to be on the increase.
1997年6月至1998年6月，在巴西马拉尼昂州拉波萨市对648名6岁以下儿童进行了一项前瞻性研究，以评估恰加斯利什曼原虫（Leishmania (Leishmania) chagasi）感染的特征，并验证营养不良与无症状感染之间是否存在关联。使用了一份标准化问卷，其中包含社会经济、环境和行为数据。进行了用亚马逊利什曼原虫的蒙氏皮肤反应（IDRM）和酶联免疫吸附测定（ELISA）检测感染，并进行了人体测量检查。通过IDRM测量的感染初始患病率、最终患病率和发病率分别为18.6%、20.6%和10.8%，根据ELISA则分别为13.5%、34.4%和28%。慢性营养不良的患病率为26%。未检测到营养不良与恰加斯利什曼原虫无症状感染之间存在关联。由于无症状感染似乎在增加，这些地区需要更有效的控制措施。
