血小板活化因子对烧伤后肠源性内毒素血症的致病作用
[Pathogenetic effect of platelet activating factor on enterogenic endotoxemia after burn].
作者信息
Yu P, Xiao G, Fu W
机构信息
Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038.
出版信息
Zhonghua Yi Xue Za Zhi. 1999 Feb;79(2):136-8.
OBJECTIVE
To investigate the effects of platelet activating factor (PAF) on the occurrence of enterogenic endotoxemia after burn.
METHODS
The relationship between changes of PAF and enterogenic endotoxima was observed on a model of rats with 30% TBSA III degree burn.
RESULTS
The intestinal permeability and plasma endotoxin were significantly elevated and were positively correlated with the increase of PAF in the intestinal tissue and blood. PAF antagonist treatment significantly decreased the intestinal permeability and the levels of plasma endotoxin. After intravenous injection of enogenous PAF to healthy rats, the intestinal permeability and plasma endotoxin were also markedly increased, which was significantly depended on the dose of PAF.
CONCLUSION
PAF is one of the important factors for the occurrence of postburn enterogenic endotoximia.
目的
探讨血小板活化因子（PAF）对烧伤后肠源性内毒素血症发生的影响。
方法
在30%总体表面积Ⅲ度烧伤大鼠模型上观察PAF变化与肠源性内毒素血症的关系。
结果
肠道通透性和血浆内毒素显著升高，且与肠道组织和血液中PAF的增加呈正相关。PAF拮抗剂治疗显著降低了肠道通透性和血浆内毒素水平。对健康大鼠静脉注射内源性PAF后，肠道通透性和血浆内毒素也明显升高，且明显依赖于PAF的剂量。
结论
PAF是烧伤后肠源性内毒素血症发生的重要因素之一。
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