[Pathogenetic effect of platelet activating factor on enterogenic endotoxemia after burn].

OBJECTIVE

To investigate the effects of platelet activating factor (PAF) on the occurrence of enterogenic endotoxemia after burn.

METHODS

The relationship between changes of PAF and enterogenic endotoxima was observed on a model of rats with 30% TBSA III degree burn.

RESULTS

The intestinal permeability and plasma endotoxin were significantly elevated and were positively correlated with the increase of PAF in the intestinal tissue and blood. PAF antagonist treatment significantly decreased the intestinal permeability and the levels of plasma endotoxin. After intravenous injection of enogenous PAF to healthy rats, the intestinal permeability and plasma endotoxin were also markedly increased, which was significantly depended on the dose of PAF.

CONCLUSION

PAF is one of the important factors for the occurrence of postburn enterogenic endotoximia.