Høidrup S, Prescott E I, Sørensen T I, Gottschau A, Lauritzen J B, Schroll M, Grønbaek M N
H:S Kommunehospitalet, Hovedstadens Center for Prospektive Befolkningsstudier, Center for Epidemiologisk Grundforskning ved Institut for Sygdomsforebyggelse.
Ugeskr Laeger. 2001 Oct 1;163(40):5532-6.
In the present population-based cohort study, we prospectively determined the influence of current, previous, and cumulative smoking history on the risk of hip fracture in men and women and addressed the issue of possible gender difference in susceptibility to tobacco smoking.
A total of 13,393 women and 17,379 men, initially examined between 1964 and 1992, were followed up until 1997 for their first admission because of hip fracture.
During follow-up, a total of 1169 hip fractures were identified. After adjustment for potential confounders, female current smokers had a relative risk of hip fracture of 1.36 (1.12-1.65) and male smoked 1.59 (1.04-2.43) relative to those who have never smoked. In both sexes, the relative risk of hip fracture gradually increased with current and accumulated tobacco consumption. A test for interaction between gender and smoking habits was insignificant. Men who stopped smoking for more than five years had a lower risk of hip fracture than men who currently smoked, whereas no such risk reduction was seen in female ex-smokers.
Tobacco smoking is an independent risk factor for hip fracture in men and women, and there appears to be no gender differences in the smoking-related risk. Men who stopped smoking for more than five years had lower risk of hip fracture than men who currently smoked, whereas no such risk reduction was seen in female ex-smokers.
在这项基于人群的队列研究中，我们前瞻性地确定了当前、既往和累积吸烟史对男性和女性髋部骨折风险的影响，并探讨了吸烟易感性方面可能存在的性别差异问题。
共有13393名女性和17379名男性，最初在1964年至1992年期间接受检查，随访至1997年，记录他们因髋部骨折首次入院的情况。
在随访期间，共确诊1169例髋部骨折。在对潜在混杂因素进行调整后，与从未吸烟的人相比，女性当前吸烟者髋部骨折的相对风险为1.36（1.12 - 1.65），男性吸烟者为1.59（1.04 - 2.43）。在两性中，髋部骨折的相对风险随着当前和累积吸烟量的增加而逐渐升高。性别与吸烟习惯之间的交互作用检验无统计学意义。戒烟超过五年的男性髋部骨折风险低于当前吸烟者，而女性戒烟者未观察到这种风险降低。
吸烟是男性和女性髋部骨折的独立危险因素，且在吸烟相关风险方面似乎不存在性别差异。戒烟超过五年的男性髋部骨折风险低于当前吸烟者，而女性戒烟者未观察到这种风险降低。
