Galkin A V, Priazhnikov E G, Sokolova E M, Giniatullin R A
Medical University, Kazan, Russia.
Ross Fiziol Zh Im I M Sechenova. 2001 Aug;87(8):1135-43.
Exogenous adenosine reduced the amplitude of multiquantal end-plate currents due to a depressant action on transmitter release. Theophylline did not change the amplitude of end-plate currents under low-rate motor nerve stimulation. The findings suggest a possibility of both tonic and phasic inhibitory actions of endogenous adenosine on transmitter release when utilization of this purine in synaptic cleft is inactivated.
外源性腺苷由于对递质释放具有抑制作用，降低了多量子终板电流的幅度。在低频率运动神经刺激下，茶碱并未改变终板电流的幅度。这些发现提示，当突触间隙中这种嘌呤的利用被灭活时，内源性腺苷对递质释放可能同时具有紧张性和位相性抑制作用。
