Giniatullin A R, Grishin S N, Giniatullin R A
Medical University, 420012, Kazan, Butlerov St., 49, Russia.
Ross Fiziol Zh Im I M Sechenova. 2000 Oct;86(10):1293-9.
Daily administration of hydrocortisone first increased and then decreased amplitude of multiquantal end-plate currents induced by motor nerve stimulation. The initial facilitating phase of the hormone action was accompanied by elimination of the ATP pre-synaptic effect. Later the inhibitory effect of the ATP becomes restored. The counteraction of the ATP effect was reproduced in the isolated muscle bathed in the saline with hydrocortisone which suggests a non-genomic action of the hormone on pre-synaptic P2 receptor. The data obtained suggest that prevention of the ATP inhibitory action might be a component of a facilitating acute stress reaction.
每日给予氢化可的松，首先会使运动神经刺激诱导的多量子终板电流幅度增加，随后降低。激素作用最初的促进阶段伴随着ATP突触前效应的消除。后来，ATP的抑制作用恢复。在含有氢化可的松的盐溶液中浸泡的离体肌肉中再现了ATP效应的对抗作用，这表明该激素对突触前P2受体具有非基因组作用。所获得的数据表明，预防ATP的抑制作用可能是促进急性应激反应的一个组成部分。
