Meziane H, Maakel M L, Vachier I, Bousquet J, Chanez P
Clinique des Maladies Respiratoires and INSERM U 454, Hospital Arnaud deVilleneuve, CHU Montpellier, France.
Respir Med. 2001 Oct;95(10):799-801. doi: 10.1053/rmed.2001.1163.
Sputum induction (IS) can be used to study airway inflammation in asthmatics and other lung diseases. However, no data are available for patients with Churg-Strauss syndrome (CSS). A study was carried out to evaluate eosinophil counts and eosinophil cationic protein (ECP) levels in induced sputum during the follow-up of three patients with CSS. Induced sputum was carried out in 10 patients with corticosteroid-dependent asthma (used as a control group). Patients with CSS had significantly higher eosinophils percentages and ECP levels in sputum than those with stable corticosteroid-dependent asthma. During the follow-up, patients with CSS presented increased ECP levels sputum and eosinophils in sputum as well as increased blood eosinophils, despite their oral corticosteroid and immunosuppressive treatment. Eosinophil percentage in sputum and the total number of eosinophils in peripheral blood were more predictive of exacerbations of CSS than sputum ECP.
痰液诱导（IS）可用于研究哮喘患者和其他肺部疾病患者的气道炎症。然而，尚无关于变应性肉芽肿性血管炎（CSS）患者的数据。开展了一项研究，以评估3例CSS患者随访期间诱导痰中的嗜酸性粒细胞计数和嗜酸性粒细胞阳离子蛋白（ECP）水平。对10例依赖皮质类固醇的哮喘患者进行了痰液诱导（作为对照组）。CSS患者痰液中的嗜酸性粒细胞百分比和ECP水平显著高于稳定的依赖皮质类固醇哮喘患者。在随访期间，CSS患者尽管接受了口服皮质类固醇和免疫抑制治疗，但痰液中的ECP水平、痰液中的嗜酸性粒细胞以及血液嗜酸性粒细胞均增加。痰液中的嗜酸性粒细胞百分比和外周血嗜酸性粒细胞总数比痰液ECP更能预测CSS的病情加重。
