与oriP相邻的序列可提高基于爱泼斯坦-巴尔病毒的附加体在B细胞中的持久性。
Sequences adjacent to oriP improve the persistence of Epstein-Barr virus-based episomes in B cells.
作者信息
White R E, Wade-Martins R, James M R
机构信息
Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom.
出版信息
J Virol. 2001 Nov;75(22):11249-52. doi: 10.1128/JVI.75.22.11249-11252.2001.
Abstract
Epstein-Barr virus (EBV) oriP and the EBV nuclear antigen 1 (EBNA-1) protein allow persistence of EBV-based episomes. A nuclear matrix attachment region (MAR) spans oriP and the adjacent region of the EBV genome containing the EBV-expressed RNAs. Here, we show that episomes with the MAR are retained significantly more efficiently in EBV-positive B cells than episomes containing oriP alone.
摘要
爱泼斯坦-巴尔病毒（EBV）的 oriP 和 EBV 核抗原 1（EBNA-1）蛋白可使基于 EBV 的附加体持续存在。一个核基质附着区域（MAR）跨越 oriP 和 EBV 基因组中包含 EBV 表达 RNA 的相邻区域。在此，我们表明，与仅含有 oriP 的附加体相比，带有 MAR 的附加体在 EBV 阳性 B 细胞中的保留效率显著更高。
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Sequences adjacent to oriP improve the persistence of Epstein-Barr virus-based episomes in B cells.与oriP相邻的序列可提高基于爱泼斯坦-巴尔病毒的附加体在B细胞中的持久性。
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本文引用的文献
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Establishment of an oriP replicon is dependent upon an infrequent, epigenetic event.oriP 复制子的建立依赖于一个罕见的表观遗传事件。
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Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP.爱泼斯坦-巴尔病毒oriP区域的可变染色质结构以及上游序列和oriP对EBER1表达的调控
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Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1.维持基于爱泼斯坦-巴尔病毒（EBV）oriP的附加体需要EBV编码的核抗原-1染色体结合结构域，该结构域可被高迁移率族-I或组蛋白H1取代。
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Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene.通过携带115 kb基因组转基因的附加体对人类细胞中的遗传缺陷进行稳定校正。
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Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.在感染已建立的细胞系后，oriP内DNA复制的起始对于潜伏性爱泼斯坦-巴尔病毒染色体的稳定复制并非必需。
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