南美洲甲型肝炎病毒的基因变异性揭示了疫情爆发期间的异质性和共同传播情况。

Genetic variability of hepatitis A virus in South America reveals heterogeneity and co-circulation during epidemic outbreaks.

作者信息

Costa-Mattioli Mauro, Ferre Virginie, Monpoeho Serge, Garcia Laura, Colina Rodney, Billaudel Sylviane, Vega Ines, Perez-Bercoff Raul, Cristina Juan

机构信息

Departamento de Técnicas Nucleares Aplicadas, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay2.

Laboratorie de Virologie, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, Rue Quai Moncousu 9, 44093 Nantes, France1.

出版信息

J Gen Virol. 2001 Nov;82(Pt 11):2647-2652. doi: 10.1099/0022-1317-82-11-2647.

DOI:10.1099/0022-1317-82-11-2647

PMID:11602776

Abstract

Genetic analysis of selected genome regions of hepatitis A virus (HAV) suggested that distinct genotypes of HAV could be found in different geographical regions. In order to gain insight into the genetic variability and mode of evolution of HAV in South America, an analysis was performed of sequence data obtained from the VP1 amino terminus and the VP1/2A region of HAV strains isolated over a short period of time in Uruguay, Argentina and Chile. Sequences obtained from 22 distinct HAV isolates were compared with published sequences from 21 different strains isolated all over the world. Phylogenetic analysis revealed that all strains isolated belong to a unique sub-genotype (IA). Strains isolated during an outbreak period showed a higher degree of heterogeneity than anticipated previously and the co-circulation of different isolates. The genetic variability among strains isolated in this region seems to be higher in comparison with strains isolated in other regions of the world.

摘要

对甲型肝炎病毒（HAV）选定基因组区域的遗传分析表明，在不同地理区域可发现不同基因型的HAV。为深入了解南美洲HAV的遗传变异性和进化模式，对在乌拉圭、阿根廷和智利短时间内分离出的HAV毒株的VP1氨基末端和VP1/2A区域获得的序列数据进行了分析。将从22个不同的HAV分离株获得的序列与从世界各地分离出的21个不同毒株的已发表序列进行了比较。系统发育分析表明，所有分离出的毒株都属于一个独特的亚基因型（IA）。在疫情暴发期间分离出的毒株显示出比先前预期更高的异质性以及不同分离株的共同流行。与世界其他地区分离出的毒株相比，该区域分离出的毒株之间的遗传变异性似乎更高。