Tecle Tesfaldet, Böttiger Blenda, Örvell Claes, Johansson Bo
Huddinge University Hospital, Department of Clinical Virology, Karolinska Institut, SE-141 86 Stockholm, Sweden1.
Statens Serum Institut, Department of Virology, Copenhagen, Denmark2.
J Gen Virol. 2001 Nov;82(Pt 11):2675-2680. doi: 10.1099/0022-1317-82-11-2675.
Twenty-nine Danish virus isolates and 14 serum samples from patients with mumps were genotyped by nucleotide sequencing of the small hydrophobic (SH) protein gene and the deduced 57 amino acid sequences were aligned with sequences of mumps virus strains published previously. Four neurovirulent genotypes of the SH protein gene, genotypes C, D, H and a new genotype, designated J, were found. There was a dynamic fluctuation of the different genotypes over the two decade period of time. Genotype J was found from 1981 to 1988; genotypes C and H exhibited a similar distribution in time. Genotype D was found between 1979 and 1982, it then disappeared and reappeared again in 1996. From 1996 onwards, genotype D was found to be the predominant genotype, which is in contrast to the situation seen in the neighbouring country of Sweden, where, since 1985, only genotype A has been found.
通过对小疏水（SH）蛋白基因进行核苷酸测序，对29株丹麦病毒分离株和14份腮腺炎患者的血清样本进行基因分型，并将推导的57个氨基酸序列与先前发表的腮腺炎病毒株序列进行比对。发现了SH蛋白基因的四种神经毒力基因型，即C、D、H型以及一种新的基因型J。在二十年的时间里，不同基因型呈现出动态波动。基因型J在1981年至1988年被发现；基因型C和H在时间上分布相似。基因型D在1979年至1982年被发现，随后消失，并于1996年再次出现。从1996年起，基因型D成为主要基因型，这与邻国瑞典的情况形成对比，在瑞典自1985年以来仅发现基因型A。
