McIntyre R S, Mancini D A, Basile V S
Department of Psychiatry, University of Toronto, Centre for Addiction and Mental Health, Ontario, Canada.
J Clin Psychiatry. 2001;62 Suppl 23:23-9.
The estimated percentage of persons with schizophrenia who are overweight is higher than the percentage of persons in the general population who are overweight. The increased mortality rate for persons with schizophrenia is largely due to obesity-related diseases. The atypical antipsychotics offer an improved therapeutic index when compared with the conventional agents, but may impart serious adverse events such as weight gain. This brief review is intended to provide the practicing clinician with an update of disparate research paradigms under investigation in an attempt to delineate the biological mechanisms that presage weight gain. Research success in this area may invite novel prevention strategies and hint at potential mechanisms of antipsychotic drug action.
精神分裂症患者中超重人群的估计百分比高于普通人群中超重人群的百分比。精神分裂症患者死亡率的增加很大程度上归因于肥胖相关疾病。与传统药物相比，非典型抗精神病药物具有更高的治疗指数，但可能会引发如体重增加等严重不良事件。本简要综述旨在为临床医生提供正在研究的不同研究范式的最新情况，以试图阐明预示体重增加的生物学机制。该领域的研究成功可能会带来新的预防策略，并暗示抗精神病药物作用的潜在机制。
