Division of General Internal Medicine, Department of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Int J Obes (Lond). 2011 Aug;35(8):1114-23. doi: 10.1038/ijo.2010.224. Epub 2010 Nov 2.
Overweight and obesity are epidemic in populations with serious mental illnesses. We developed and pilot-tested a behavioral weight-loss intervention appropriately tailored for persons with serious mental disorders.
We conducted a single-arm pilot study in two psychiatric rehabilitation day programs in Maryland, and enrolled 63 overweight or obese adults. The 6-month intervention provided group and individual weight management and group physical activity classes. The primary outcome was weight change from baseline to 6 months.
A total of 64% of those potentially eligible enrolled at the centers. The mean age was 43.7 years; 56% were women; 49% were white; and over half had schizophrenia or a schizoaffective disorder. One-third had hypertension and one-fifth had diabetes. In total, 52 (82%) completed the study; others were discharged from psychiatric centers before completion of the study. Average attendance across all weight management sessions was 70% (87% on days participants attended the center) and 59% for physical activity classes (74% on days participants attended the center). From a baseline mean of 210.9 lbs (s.d. 43.9), average weight loss for 52 participants was 4.5 lb (s.d. 12.8) (P<0.014). On average, participants lost 1.9% of body weight. Mean waist circumference change was 3.1 cm (s.d. 5.6). Participants on average increased the distance on the 6-minute walk test by 8%.
This pilot study documents the feasibility and preliminary efficacy of a behavioral weight-loss intervention in adults with serious mental illness who were attendees at psychiatric rehabilitation centers. The results may have implications for developing weight-loss interventions in other institutional settings such as schools or nursing homes.
超重和肥胖在患有严重精神疾病的人群中普遍存在。我们为严重精神障碍患者量身定制了一项行为减肥干预措施,并对其进行了开发和试点测试。
我们在马里兰州的两个精神病康复日间项目中进行了一项单臂试点研究,共纳入 63 名超重或肥胖成年人。为期 6 个月的干预措施提供了团体和个体体重管理以及团体体育活动课程。主要结局是从基线到 6 个月的体重变化。
两个中心共有 64%的潜在合格人员入组。参与者的平均年龄为 43.7 岁;56%为女性;49%为白人;超过一半的人患有精神分裂症或分裂情感障碍。三分之一的人患有高血压,五分之一的人患有糖尿病。共有 52 人(82%)完成了研究;其他人在完成研究之前从精神病中心出院。所有体重管理课程的平均出勤率为 70%(参与者在中心出勤的天数为 87%),体育活动课程的出勤率为 59%(参与者在中心出勤的天数为 74%)。从基线平均 210.9 磅(标准差 43.9)开始,52 名参与者的平均体重减轻了 4.5 磅(标准差 12.8)(P<0.014)。平均而言,参与者减轻了 1.9%的体重。平均腰围变化为 3.1 厘米(标准差 5.6)。参与者的 6 分钟步行测试距离平均增加了 8%。
这项试点研究记录了一项针对在精神病康复中心就诊的患有严重精神疾病的成年人的行为减肥干预措施的可行性和初步疗效。这些结果可能对在其他机构环境(如学校或疗养院)中开发减肥干预措施具有启示意义。