Trager J, Ward M M
Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Curr Opin Rheumatol. 2001 Sep;13(5):345-51. doi: 10.1097/00002281-200109000-00002.
Cohort studies of survival in systemic lupus erythematosus (SLE) often have been limited by methodologic problems. In studies of inception cohorts of patients followed since 1980, survival at 5 years has exceeded 90%. These estimates are generally higher than survival estimates from earlier studies, suggesting that short-term survival in SLE has improved. There is less evidence to support major improvements over time in survival after 10 years or more of SLE. Infections, atherosclerotic disease, and active systemic lupus erythematosus or organ damage caused by SLE are the main causes of death in patients with SLE, but the proportion of early deaths caused by active SLE has decreased over time.
系统性红斑狼疮（SLE）生存情况的队列研究常常受到方法学问题的限制。在对自1980年起随访的患者起始队列研究中，5年生存率超过了90%。这些估计值通常高于早期研究的生存估计值，表明SLE的短期生存率有所改善。几乎没有证据支持SLE发病10年或更长时间后生存情况随时间有重大改善。感染、动脉粥样硬化疾病以及活动性系统性红斑狼疮或SLE所致的器官损害是SLE患者的主要死亡原因，但活动性SLE导致的早期死亡比例随时间已有所下降。
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