Ward M M, Pyun E, Studenski S
Palo Alto Veterans Affairs Medical Center, CA 94304, USA.
Arthritis Rheum. 1995 Oct;38(10):1492-9. doi: 10.1002/art.1780381016.
To describe the causes of death in a cohort of patients with systemic lupus erythematosus (SLE), and to determine if the major causes of death differ according to patient age, sex, race, socioeconomic status, and the duration of SLE.
We examined survival in a cohort of 408 patients with SLE. During a median of 11 years of followup, 144 patients died. The cause of death was determined for 134 patients (93%).
SLE was the most common cause of death, occurring in 49 patients (34%), followed by infection (n = 32; 22%), cardiovascular disease (n = 23; 16%), cerebrovascular disease (n = 8; 6%), and cancer (n = 8; 6%). Deaths due to SLE and due to infections were more common among younger patients, and deaths due to cancer were more common among older patients. Although the risk of death due to SLE was greatest during the first 3 years after diagnosis, deaths due to SLE occurred throughout the course of disease.
In this study of patients with SLE who were followed up for an extended period of time beginning soon after diagnosis, SLE was the most common cause of death, and deaths due to SLE occurred throughout the course of illness.
描述一组系统性红斑狼疮（SLE）患者的死亡原因，并确定主要死亡原因是否因患者年龄、性别、种族、社会经济地位和SLE病程而异。
我们研究了408例SLE患者的生存情况。在中位随访11年期间，144例患者死亡。确定了134例患者（93%）的死亡原因。
SLE是最常见的死亡原因，49例（34%），其次是感染（n = 32；22%）、心血管疾病（n = 23；16%）、脑血管疾病（n = 8；6%）和癌症（n = 8；6%）。SLE和感染导致的死亡在年轻患者中更常见，癌症导致的死亡在老年患者中更常见。虽然诊断后前3年SLE导致的死亡风险最大，但SLE导致的死亡在疾病全过程中均有发生。
在这项对诊断后不久开始长期随访的SLE患者的研究中，SLE是最常见的死亡原因，且SLE导致的死亡在疾病全过程中均有发生。
