放线菌素D治疗骨佩吉特病
Actinomycin D in the treatment of Paget's disease of bone.
作者信息
Somerville P J, Evans R A
出版信息
Med J Aust. 1975 Jul 5;2(1):13-6. doi: 10.5694/j.1326-5377.1975.tb95071.x.
Abstract
Fifteen patients with Paget's disease of bone were treated with actinomycin D for periods of up to 15 months. It was found that actinomycin D is effective in reducing the pain but not the neurological effects of Paget's disease. Careful adjustment of dose according to weight and initial response is necessary to prevent gastrointestinal side effects. If this is done, the risk of hepatic, renal, or haematological side effects is negligible.
摘要
15例骨佩吉特病患者接受了放线菌素D治疗，疗程长达15个月。结果发现，放线菌素D在减轻骨佩吉特病的疼痛方面有效，但对其神经学影响无效。根据体重和初始反应仔细调整剂量对于预防胃肠道副作用很有必要。如果做到这一点，肝、肾或血液学副作用的风险可以忽略不计。
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