Davis H L, von Hoff D D, Henney J E, Rozencweig M
Cancer Chemother Pharmacol. 1978;1(2):83-90. doi: 10.1007/BF00254041.
The antitumor antibiotics have thus made a major impact on oncologic practice. The continued search for productive strains of these organisms should be encouraged; in addition, the activity and toxicity spectrum suggests the need for vigorous analogue development. An active anthracycline devoid of cardiotoxicity, a bleomycin with no effect on pulmonary tissue, an analogue of streptozoticin devoid of nephrotoxicity -- these would be advances of inestimable benefit to the cancer patient of the future.
因此，抗肿瘤抗生素对肿瘤学实践产生了重大影响。应鼓励继续寻找这些微生物的高产菌株；此外，其活性和毒性谱表明需要大力开展类似物研发。一种无心脏毒性的活性蒽环类药物、一种对肺组织无影响的博来霉素、一种无肾毒性的链脲佐菌素类似物——这些将是对未来癌症患者有不可估量益处的进展。
