Sakai K
Kyushu Women's University.
Yakushigaku Zasshi. 1994;29(3):435-40.
One century has passed since fugu toxin was first named tetrodotoxin by Tahara. Chemical problems such as crystallization of tetrodotoxin, followed by structure determination by the research groups headed by Tsuda, Hirata, Woodward, and Mosher, and its subsequent synthesis by Kishi have been solved. In the last 10 years, research on the distribution of tetrodotoxin in nature has shown that tetrodotoxin is not produced by fugu fish, but rather is formed by sea bacteria such as Vibrio, Alteromonas, Photobacterium, and Aeomonas. However, it remains unclear why tetrodotoxin accumulates at a high concentration only in fugu.
自田原将河豚毒素首次命名为河鲀毒素以来，已经过去了一个世纪。诸如河鲀毒素的结晶等化学问题，随后由津田、平田、伍德沃德和莫舍领导的研究小组确定其结构，以及随后岸义人对其进行合成等问题都已得到解决。在过去的十年里，对河鲀毒素在自然界分布的研究表明，河鲀毒素并非由河豚鱼产生，而是由诸如弧菌属、交替单胞菌属、发光杆菌属和气单胞菌属等海洋细菌形成。然而，河鲀毒素为何仅在河豚体内高浓度积累仍不清楚。
