Nakayama H
Faculty of Pharmaceutical Sciences, Kumamoto University.
Yakushigaku Zasshi. 1994;29(3):441-5.
Since Dr. Y. Tawara started investigation of the lethal paralytic toxin (tetrodotoxin) from globefish just 100 years ago, Japanese researchers have contributed greatly at every stage of its chemical and pharmacological analysis as well as to the molecular studies which led to the discovery of the sodium channel as its target. On this special ocasion, I briefly review the pharmacology of tetrodotoxin and the molecular structure of the sodium channel.
自约100年前田原良纯博士开始对河豚的致命麻痹毒素（河豚毒素）展开研究以来，日本研究人员在该毒素的化学和药理学分析的各个阶段，以及在导致发现其靶点——钠通道的分子研究方面都做出了巨大贡献。在这个特殊时刻，我简要回顾一下河豚毒素的药理学以及钠通道的分子结构。
