[日本药典（JP）（第8部分）中精神药物的转变。日本药典（JP）中巴比妥类药物、催眠药和镇静剂的采用以及标准和测试方法的转变]
[The transition of psychotropic drugs in Japanese Pharmacopoeia (JP) (Part 8). The adoptiion of barbiturates, hypnotics and sedatives in Japanese Pharmacopoeia (JP) and transition of the standards and the test methods].
作者信息
Yanagisawa K, Yamada M, Matsumoto Y
机构信息
The Japanese Society for History of Pharmacy.
出版信息
Yakushigaku Zasshi. 1995;30(1):36-45.
This is the study on the transition of the standards and test methods for barbiturates drugs (Bar-d) between JP IV (1920) and JP XII (1991). The results are as follows: Many new Bar-d appeared between JP VI (1951) and JP VIII (1971). Then many kinds of test methods for Bar-d were studied between JP VII (1961) and JP VIII (1971) and common and precise test methods were established. It is thought that Bar-d were used widely as hypnotics and sedatives in the 1960's in Japan, but some Bar-d were eliminated since JP IX (1976). The test methods for Bar-d were never revised after JP VIII (1971). It is thought that the first choice drugs for hypnotics and sedatives in Japan have transferred from Bromides and Bar-d to Benzodiazepines and the demand of Bar-d as hypnotics and sedatives has declined.
这是一项关于日本药局方第四版（1920年）至日本药局方第十二版（1991年）中巴比妥类药物（Bar-d）标准及检测方法变迁的研究。结果如下：在日本药局方第六版（1951年）至日本药局方第八版（1971年）之间出现了许多新的Bar-d。随后在日本药局方第七版（1961年）至日本药局方第八版（1971年）之间对多种Bar-d检测方法进行了研究，并确立了通用且精确的检测方法。据认为，20世纪60年代巴比妥类药物在日本被广泛用作催眠药和镇静剂，但自日本药局方第九版（1976年）起一些Bar-d被淘汰。自日本药局方第八版（1971年）之后Bar-d的检测方法从未修订。据认为，日本催眠药和镇静剂的首选药物已从溴化物和巴比妥类药物转变为苯二氮䓬类药物，巴比妥类药物作为催眠药和镇静剂的需求已经下降。
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