Rossi G L, Probst D, Panerai A E, Cocchi D, Locatelli V, Müller E E
Neuroendocrinology. 1979;29(2):100-9. doi: 10.1159/000122911.
Anterior pituitaries from female Sprague-Dawley rats (160-200 g b.w) bearing electrolytic lesions of the median eminence were qualitatively and quantitatively investigated by electron microscopy and the findings compared with those from intact animals or sham-operated controls. This study was performed in basal conditions and after stimulation with thyrotropin-releasing hormone. Animals with lesions showed a reduction of both the number of somatotrophic cells and growth hormone granules. After injection of thyrotropin-releasing hormone exocytosis of growth hormone granules from somatotrophs was frequent in rats with lesions of the median eminence but rare in sham-operated animals. The differences were statistically significant.
对患有正中隆起电解损伤的雌性斯普拉格-道利大鼠（体重160 - 200克）的垂体前叶进行了定性和定量的电子显微镜研究，并将结果与完整动物或假手术对照组的结果进行了比较。本研究在基础条件下以及促甲状腺激素释放激素刺激后进行。有损伤的动物生长激素细胞数量和生长激素颗粒均减少。注射促甲状腺激素释放激素后，正中隆起有损伤的大鼠促生长激素细胞中生长激素颗粒的胞吐作用频繁，而假手术动物中则很少见。差异具有统计学意义。
