Rossi G L, Bestetti G
Diabetologia. 1981 Nov;21(5):476-81. doi: 10.1007/BF00257789.
The hypothalami, pituitaries and testes from streptozotocin-treated and control male Wistar rats were examined by light and electron microscopy 12 months after induction of diabetes. Light and electron microscopic immunohistochemical techniques were employed for the localization of luteinizing hormone-releasing hormone and luteinizing hormone in the hypothalami and the pituitaries. In the hypothalami of diabetic animals swollen neuronal processes containing anti-luteinizing hormone-releasing-hormone positive material were frequent. In the pituitaries of the same animals a large number of small luteinizing hormone-gonadotrophs was found. These cells contained numerous secretory granules and were deficient in endoplasmic reticulum. The average testicular weight of the diabetic rats was significantly reduced but with marked individual variations. Histologically, the testes with the highest weights appeared normal, those with the lowest weights atrophic with few degenerating Leydig cells. these hypothalamic-hypophyseal changes are probably responsible for the testicular lesions found in experimental diabetes mellitus and may have relevance to the problem of infertility in human diabetes.
在诱导糖尿病12个月后，通过光学显微镜和电子显微镜检查了链脲佐菌素处理的雄性Wistar大鼠和对照大鼠的下丘脑、垂体和睾丸。采用光学和电子显微镜免疫组织化学技术对下丘脑和垂体中的促黄体生成激素释放激素和促黄体生成激素进行定位。在糖尿病动物的下丘脑中，含有抗促黄体生成激素释放激素阳性物质的肿胀神经元突起很常见。在同一动物的垂体中，发现了大量小的促黄体生成激素促性腺细胞。这些细胞含有大量分泌颗粒，内质网缺乏。糖尿病大鼠的平均睾丸重量显著降低，但个体差异明显。组织学上，睾丸重量最高的看起来正常，睾丸重量最低的萎缩，仅有少数退化的睾丸间质细胞。这些下丘脑 - 垂体的变化可能是实验性糖尿病中发现的睾丸病变的原因，并且可能与人类糖尿病中的不育问题有关。
