Wilson E
Departamento de Neurocirugia, Instituto de Neurologia, Montevideo, Uruguay.
J Hist Neurosci. 1997 Apr;6(1):82-5. doi: 10.1080/09647049709525688.
Soon after the discovery of the tetanus antitoxin, animal experiments led to the conclusion that intracerebral injection of the antitoxin would be useful in the treatment of tetanus. The French surgeon Quenu carried out the first injection and gave a description of the neurosurgical technique required. The method was applied in other European countries until it was declared to be less efficient than simple subcutaneous or intravenous injections. Outside Europe, intracerebral injections of tetanus antitoxin were reported and photographed in Montevideo, Uruguay, in 1901.
破伤风抗毒素被发现后不久，动物实验得出结论，脑内注射抗毒素对破伤风治疗有效。法国外科医生凯尼进行了首次注射，并描述了所需的神经外科技术。该方法在其他欧洲国家得到应用，直到后来被宣称不如简单的皮下或静脉注射有效。在欧洲以外，1901年在乌拉圭蒙得维的亚有人报道并拍摄了破伤风抗毒素脑内注射的情况。
